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Structure of Leucine Rich Repeat Kinase 2's ROC domain interacting with the microtubule facing the minus end

Electron Microscopy
5.2Å resolution
PDB entry 7thy coloured by chain, ensemble of 5 models, front view.
PDB entry 7thy coloured by chain, ensemble of 5 models, side view.
PDB entry 7thy coloured by chain, ensemble of 5 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Leucine-rich repeat serine/threonine-protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 11259.81 Å2
Buried surface area: 775.99 Å2
Dissociation area: 387.99 Å2
Dissociation energy (ΔGdiss): 7.39 kcal/mol
Dissociation entropy (TΔSdiss): 5.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-177793

Macromolecules

Leucine-rich repeat serine/threonine-protein kinase 2
Chain: A
Length: 194 amino acids
Theoretical weight: 22.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5S007 (Residues: 1332-1525; Coverage: 8%)
Gene names: LRRK2, PARK8
Pfam: Ras of Complex, Roc, domain of DAPkinase
InterPro:
Leucine-rich repeat serine/threonine-protein kinase 2 in PDB entry 7thy, assembly 1, front view.
Leucine-rich repeat serine/threonine-protein kinase 2 in PDB entry 7thy, assembly 1, side view.
Leucine-rich repeat serine/threonine-protein kinase 2 in PDB entry 7thy, assembly 1, top view.
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