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Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs

Source organism: Homo sapiens
Biochemical function: sodium channel regulator activity
Biological process: sodium ion transport
Cellular component: voltage-gated sodium channel complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00520
Domain description: Ion transport protein
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
The deposited structure of PDB entry 7tj8 contains 4 copies of Pfam domain PF00520 (Ion transport protein) in Sodium channel protein type 7 subunit alpha. Showing 4 copies in chain A.

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Sodium channel regulatory subunit beta-3
The deposited structure of PDB entry 7tj8 contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Sodium channel subunit beta-3. Showing 1 copy in chain B.

PF06512
Domain description: Sodium ion transport-associated
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
The deposited structure of PDB entry 7tj8 contains 1 copy of Pfam domain PF06512 (Sodium ion transport-associated) in Sodium channel protein type 7 subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005821
Domain description: Ion transport domain
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
IPR027359
Domain description: Voltage-dependent channel domain superfamily
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
IPR001696
Domain description: Voltage gated sodium channel, alpha subunit
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Sodium channel regulatory subunit beta-3
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Sodium channel regulatory subunit beta-3
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Sodium channel regulatory subunit beta-3
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Sodium channel regulatory subunit beta-3
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Sodium channel regulatory subunit beta-3
IPR027098
Domain description: Sodium channel subunit beta-1/beta-3
Occurring in:
  1. Sodium channel regulatory subunit beta-3
IPR044564
Domain description: Voltage-gated sodium channel alpha subunit, inactivation gate
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
IPR010526
Domain description: Sodium ion transport-associated domain
Occurring in:
  1. Sodium channel protein type 7 subunit alpha
IPR043203
Domain description: Voltage-gated cation channel calcium and sodium
Occurring in:
  1. Sodium channel protein type 7 subunit alpha

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