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S. cerevisiae ORC bound to 84 bp ARS1 DNA

Electron Microscopy
2.6Å resolution
PDB entry 7tjf coloured by chain, front view.
PDB entry 7tjf coloured by chain, side view.
PDB entry 7tjf coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
hetero octamer (preferred)
Entry contents: 6 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Origin recognition complex and DNA
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Multimeric state: hetero octamer
Accessible surface area: 105544.71 Å2
Buried surface area: 53257.24 Å2
Dissociation area: 3,088.07 Å2
Dissociation energy (ΔGdiss): 35.7 kcal/mol
Dissociation entropy (TΔSdiss): 14.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-122097

Macromolecules

Origin recognition complex subunit 1
Chain: A
Length: 917 amino acids
Theoretical weight: 104.82 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54784 (Residues: 1-914; Coverage: 100%)
Gene names: ORC1, YML065W
Pfam:
InterPro:
Origin recognition complex subunit 1 in PDB entry 7tjf, assembly 1, front view.
Origin recognition complex subunit 1 in PDB entry 7tjf, assembly 1, side view.
Origin recognition complex subunit 1 in PDB entry 7tjf, assembly 1, top view.
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Origin recognition complex subunit 2
Chain: B
Length: 620 amino acids
Theoretical weight: 71.34 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P32833 (Residues: 1-620; Coverage: 100%)
Gene names: ORC2, RRR1, SIR5, YBR0523, YBR060C
Pfam: Origin recognition complex subunit 2
InterPro: Origin recognition complex, subunit 2
Origin recognition complex subunit 2 in PDB entry 7tjf, assembly 1, front view.
Origin recognition complex subunit 2 in PDB entry 7tjf, assembly 1, side view.
Origin recognition complex subunit 2 in PDB entry 7tjf, assembly 1, top view.
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Origin recognition complex subunit 3
Chain: C
Length: 616 amino acids
Theoretical weight: 72.16 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54790 (Residues: 1-616; Coverage: 100%)
Gene names: L1365, OAF1, OIF1, ORC3, YLL004W
Pfam:
InterPro:
Origin recognition complex subunit 3 in PDB entry 7tjf, assembly 1, front view.
Origin recognition complex subunit 3 in PDB entry 7tjf, assembly 1, side view.
Origin recognition complex subunit 3 in PDB entry 7tjf, assembly 1, top view.
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Origin recognition complex subunit 4
Chain: D
Length: 532 amino acids
Theoretical weight: 61.04 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54791 (Residues: 1-529; Coverage: 100%)
Gene names: ORC4, P9325.5, YPR162C
Pfam: Origin recognition complex (ORC) subunit 4 C-terminus
InterPro:
Origin recognition complex subunit 4 in PDB entry 7tjf, assembly 1, front view.
Origin recognition complex subunit 4 in PDB entry 7tjf, assembly 1, side view.
Origin recognition complex subunit 4 in PDB entry 7tjf, assembly 1, top view.
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Origin recognition complex subunit 5
Chain: E
Length: 479 amino acids
Theoretical weight: 55.35 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P50874 (Residues: 1-479; Coverage: 100%)
Gene names: N0834, ORC5, YNL261W
Pfam:
InterPro:
Origin recognition complex subunit 5 in PDB entry 7tjf, assembly 1, front view.
Origin recognition complex subunit 5 in PDB entry 7tjf, assembly 1, side view.
Origin recognition complex subunit 5 in PDB entry 7tjf, assembly 1, top view.
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Origin recognition complex subunit 6
Chain: F
Length: 435 amino acids
Theoretical weight: 50.37 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P38826 (Residues: 1-435; Coverage: 100%)
Gene names: AAP1, ORC6, YHR118C
Pfam: Origin recognition complex subunit 6 (ORC6)
InterPro:
Origin recognition complex subunit 6 in PDB entry 7tjf, assembly 1, front view.
Origin recognition complex subunit 6 in PDB entry 7tjf, assembly 1, side view.
Origin recognition complex subunit 6 in PDB entry 7tjf, assembly 1, top view.
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DNA chain G
Name: DNA, 84 bp ARS1
Representative chains: G
Length: 84 nucleotides
Theoretical weight: 25.82 KDa
DNA, 84 bp ARS1 in PDB entry 7tjf, assembly 1, front view.
DNA, 84 bp ARS1 in PDB entry 7tjf, assembly 1, side view.
DNA, 84 bp ARS1 in PDB entry 7tjf, assembly 1, top view.
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DNA chain H
Name: DNA, 84 bp ARS1
Representative chains: H
Length: 84 nucleotides
Theoretical weight: 25.98 KDa
DNA, 84 bp ARS1 in PDB entry 7tjf, assembly 1, front view.
DNA, 84 bp ARS1 in PDB entry 7tjf, assembly 1, side view.
DNA, 84 bp ARS1 in PDB entry 7tjf, assembly 1, top view.
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