› 7tps

X-ray diffraction
3.15Å resolution

Crystal structure of ALPN-202 (engineered CD80 vIgD) in complex with PD-L1

Released:
DOI: 10.2210/pdb7tps/pdb
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PDB entry 7tps coloured by chain, front view.
PDB entry 7tps coloured by chain, side view.
PDB entry 7tps coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL
OpenAccess logo Nat Commun 13 1790 (2022)
PMID: 35379805

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152639 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
T-lymphocyte activation antigen CD80 Chains: A, C
Molecule details ›
Chains: A, C
Length: 106 amino acids
Theoretical weight: 12.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P33681 (Residues: 35-140; Coverage: 42%)
Gene names: CD28LG, CD28LG1, CD80, LAB7
Sequence domains: Immunoglobulin V-set domain
Programmed cell death 1 ligand 1 Chain: B
Molecule details ›
Chain: B
Length: 209 amino acids
Theoretical weight: 24.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZQ7 (Residues: 19-227; Coverage: 77%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains:
Programmed cell death 1 ligand 1 Chain: D

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 6 x NAG
Ligand GOL 1 x GOL
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 59.928Å b: 122.152Å c: 152.675Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.247 0.291
Expression system: Homo sapiens

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Citations

2 review citations

Immune checkpoint inhibitor-associated cardiovascular toxicities: A review.
Liu et al. (2024)
1 more

2 mentions without citation

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer et al. (2022)
1 more

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