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Crystal structure of ALPN-202 (engineered CD80 vIgD) in complex with PD-L1

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T-lymphocyte activation antigen CD80
  2. Programmed cell death 1 ligand 1
  3. Programmed cell death 1 ligand 1
The deposited structure of PDB entry 7tps contains 2 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in T-lymphocyte activation antigen CD80. Showing 1 copy in chain A.
The deposited structure of PDB entry 7tps contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Programmed cell death 1 ligand 1. Showing 1 copy in chain B.
The deposited structure of PDB entry 7tps contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Programmed cell death 1 ligand 1. Showing 1 copy in chain D.

PF08205
Domain description: CD80-like C2-set immunoglobulin domain
Occurring in:
  1. Programmed cell death 1 ligand 1
  2. Programmed cell death 1 ligand 1
The deposited structure of PDB entry 7tps contains 1 copy of Pfam domain PF08205 (CD80-like C2-set immunoglobulin domain ) in Programmed cell death 1 ligand 1. Showing 1 copy in chain B.
The deposited structure of PDB entry 7tps contains 1 copy of Pfam domain PF08205 (CD80-like C2-set immunoglobulin domain ) in Programmed cell death 1 ligand 1. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. T-lymphocyte activation antigen CD80
  2. Programmed cell death 1 ligand 1
  3. Programmed cell death 1 ligand 1
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. T-lymphocyte activation antigen CD80
  2. Programmed cell death 1 ligand 1
  3. Programmed cell death 1 ligand 1
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. T-lymphocyte activation antigen CD80
  2. Programmed cell death 1 ligand 1
  3. Programmed cell death 1 ligand 1
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. T-lymphocyte activation antigen CD80
  2. Programmed cell death 1 ligand 1
  3. Programmed cell death 1 ligand 1
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T-lymphocyte activation antigen CD80
  2. Programmed cell death 1 ligand 1
  3. Programmed cell death 1 ligand 1
IPR013162
Domain description: CD80-like, immunoglobulin C2-set
Occurring in:
  1. Programmed cell death 1 ligand 1
  2. Programmed cell death 1 ligand 1
IPR042711
Domain description: CD80, immunoglobulin variable domain
Occurring in:
  1. T-lymphocyte activation antigen CD80

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