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Cryo-EM structure of human ankyrin complex (B4P1A1) from red blood cell

Electron Microscopy
5.6Å resolution
PDB entry 7tw6 coloured by chain, front view.
PDB entry 7tw6 coloured by chain, side view.
PDB entry 7tw6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 161264.57 Å2
Buried surface area: 19408.14 Å2
Dissociation area: 1,641.42 Å2
Dissociation energy (ΔGdiss): -23.99 kcal/mol
Dissociation entropy (TΔSdiss): 31.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136117

Macromolecules

Band 3 anion transport protein
Chains: A, B, J, K
Length: 911 amino acids
Theoretical weight: 101.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02730 (Residues: 1-911; Coverage: 100%)
Gene names: AE1, DI, EPB3, SLC4A1
Pfam:
InterPro:
Band 3 anion transport protein in PDB entry 7tw6, assembly 1, front view.
Band 3 anion transport protein in PDB entry 7tw6, assembly 1, side view.
Band 3 anion transport protein in PDB entry 7tw6, assembly 1, top view.
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Protein 4.2
Chain: E
Length: 691 amino acids
Theoretical weight: 77.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16452 (Residues: 1-691; Coverage: 100%)
Gene names: E42P, EPB42
Pfam:
InterPro:
Protein 4.2 in PDB entry 7tw6, assembly 1, front view.
Protein 4.2 in PDB entry 7tw6, assembly 1, side view.
Protein 4.2 in PDB entry 7tw6, assembly 1, top view.
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Ankyrin-1
Chain: G
Length: 1881 amino acids
Theoretical weight: 206.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16157 (Residues: 1-1881; Coverage: 100%)
Gene names: ANK, ANK1
Pfam:
InterPro:
Ankyrin-1 in PDB entry 7tw6, assembly 1, front view.
Ankyrin-1 in PDB entry 7tw6, assembly 1, side view.
Ankyrin-1 in PDB entry 7tw6, assembly 1, top view.
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