› 7u23

Electron Microscopy
4.6Å resolution

Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form

Released:
DOI: 10.2210/pdb7u23/pdb
PDB entry 7u23 coloured by chain, front view.
PDB entry 7u23 coloured by chain, side view.
PDB entry 7u23 coloured by chain, top view.
Source organisms:
Primary publication:
Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinová M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C
OpenAccess logo Nat Commun 13 6700 (2022)
PMID: 36335114
Related structures: EMD-26306

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139912 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like growth factor 1 receptor alpha chain Chains: E, F
Molecule details ›
Chains: E, F
Length: 952 amino acids
Theoretical weight: 108.94 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08069 (Residues: 31-935; Coverage: 68%)
Gene name: IGF1R
Sequence domains:
single-chain LCDV-1 viral insulin-like peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 62 amino acids
Theoretical weight: 6.73 KDa
Source organism: Lymphocystis disease virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-26306
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

2 review citations

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma.
Yasir et al. (2023)
1 more

1 mention without citation

Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities.
Lin et al. (2023)