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Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form

Electron Microscopy
4.6Å resolution
PDB entry 7u23 coloured by chain, front view.
PDB entry 7u23 coloured by chain, side view.
PDB entry 7u23 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: hetero tetramer
Accessible surface area: 75271.76 Å2
Buried surface area: 9921.82 Å2
Dissociation area: 1,624.34 Å2
Dissociation energy (ΔGdiss): 4.75 kcal/mol
Dissociation entropy (TΔSdiss): 11.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139912

Macromolecules

Insulin-like growth factor 1 receptor alpha chain
Chains: E, F
Length: 952 amino acids
Theoretical weight: 108.94 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08069 (Residues: 31-935; Coverage: 68%)
Gene name: IGF1R
Pfam:
InterPro:
Insulin-like growth factor 1 receptor alpha chain in PDB entry 7u23, assembly 1, front view.
Insulin-like growth factor 1 receptor alpha chain in PDB entry 7u23, assembly 1, side view.
Insulin-like growth factor 1 receptor alpha chain in PDB entry 7u23, assembly 1, top view.
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single-chain LCDV-1 viral insulin-like peptide
Chains: C, D
Length: 62 amino acids
Theoretical weight: 6.73 KDa
Source organism: Lymphocystis disease virus 1
Expression system: Not provided
InterPro:
single-chain LCDV-1 viral insulin-like peptide in PDB entry 7u23, assembly 1, front view.
single-chain LCDV-1 viral insulin-like peptide in PDB entry 7u23, assembly 1, side view.
single-chain LCDV-1 viral insulin-like peptide in PDB entry 7u23, assembly 1, top view.
Molecule details ›

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