EC 5.2.1.8: Peptidylprolyl isomerase
Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
- Cyclophilin
- PPIase
- Peptide bond isomerase
- Peptidyl-prolyl cis-trans isomerase
- Peptidylprolyl cis-trans isomerase
- Rotamase
Protein families (Pfam)![The deposited structure of PDB entry 7u9r contains 16 copies of Pfam domain PF02026 (RyR domain) in Ryanodine receptor 2. Showing 4 copies in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF02026_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 16 copies of Pfam domain <span class='highlight'>PF02026 (RyR domain)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 4 copies in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 12 copies of Pfam domain PF00622 (SPRY domain) in Ryanodine receptor 2. Showing 3 copies in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF00622_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 12 copies of Pfam domain <span class='highlight'>PF00622 (SPRY domain)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 3 copies in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 8 copies of Pfam domain PF01365 (RIH domain) in Ryanodine receptor 2. Showing 2 copies in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF01365_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 8 copies of Pfam domain <span class='highlight'>PF01365 (RIH domain)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 2 copies in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 4 copies of Pfam domain PF00254 (FKBP-type peptidyl-prolyl cis-trans isomerase) in Peptidyl-prolyl cis-trans isomerase FKBP1B. Showing 1 copy in chain C [auth E].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_1_E_Pfam_PF00254_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 4 copies of Pfam domain <span class='highlight'>PF00254 (FKBP-type peptidyl-prolyl cis-trans isomerase)</span> in <span class='highlight'>Peptidyl-prolyl cis-trans isomerase FKBP1B</span>. Showing 1 copy in chain <span class='highlight'>C [auth E]</span>.")
![The deposited structure of PDB entry 7u9r contains 4 copies of Pfam domain PF00520 (Ion transport protein) in Ryanodine receptor 2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF00520_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 4 copies of Pfam domain <span class='highlight'>PF00520 (Ion transport protein)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 4 copies of Pfam domain PF06459 (Ryanodine Receptor TM 4-6) in Ryanodine receptor 2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF06459_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 4 copies of Pfam domain <span class='highlight'>PF06459 (Ryanodine Receptor TM 4-6)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 4 copies of Pfam domain PF08454 (RyR and IP3R Homology associated) in Ryanodine receptor 2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF08454_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 4 copies of Pfam domain <span class='highlight'>PF08454 (RyR and IP3R Homology associated)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 4 copies of Pfam domain PF02815 (MIR domain) in Ryanodine receptor 2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF02815_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 4 copies of Pfam domain <span class='highlight'>PF02815 (MIR domain)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 7u9r contains 4 copies of Pfam domain PF08709 (Inositol 1,4,5-trisphosphate/ryanodine receptor) in Ryanodine receptor 2. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7u9r_2_A_Pfam_PF08709_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7u9r</span> contains 4 copies of Pfam domain <span class='highlight'>PF08709 (Inositol 1,4,5-trisphosphate/ryanodine receptor)</span> in <span class='highlight'>Ryanodine receptor 2</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotations