7ugo

Electron Microscopy
4.1Å resolution

Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-278786 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (13 distinct):
Envelope glycoprotein gp160 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 466 amino acids
Theoretical weight: 52.32 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 129 amino acids
Theoretical weight: 14.68 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
10-1074 Fab heavy chain Chains: M, N, O
10-1074 Fab light chain Chains: P, Q, R
BG24 inferred germline Fab with mature CDR3s heavy chain Chains: G, H, I
BG24 inferred germline Fab with mature CDR3s light chain Chains: J, K, L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-26492
Expression system: Homo sapiens