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Human GATOR2 complex

Electron Microscopy
3.66Å resolution
PDB entry 7uhy coloured by chain, front view.
PDB entry 7uhy coloured by chain, side view.
PDB entry 7uhy coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero icosamer (preferred)
Entry contents: 7 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero icosamer
Accessible surface area: 330295.31 Å2
Buried surface area: 79649.77 Å2
Dissociation area: 583.58 Å2
Dissociation energy (ΔGdiss): -12.76 kcal/mol
Dissociation entropy (TΔSdiss): 22.18 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-157305

Macromolecules

GATOR2 complex protein MIOS
Chains: A, B
Length: 894 amino acids
Theoretical weight: 100.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NXC5 (Residues: 1-875; Coverage: 100%)
Gene name: MIOS
Pfam:
InterPro:
GATOR2 complex protein MIOS in PDB entry 7uhy, assembly 1, front view.
GATOR2 complex protein MIOS in PDB entry 7uhy, assembly 1, side view.
GATOR2 complex protein MIOS in PDB entry 7uhy, assembly 1, top view.
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GATOR2 complex protein WDR24
Chain: C
Length: 790 amino acids
Theoretical weight: 88.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96S15 (Residues: 1-790; Coverage: 100%)
Gene names: C16orf21, JFP7, WDR24
Pfam: WD domain, G-beta repeat
InterPro:
GATOR2 complex protein WDR24 in PDB entry 7uhy, assembly 1, front view.
GATOR2 complex protein WDR24 in PDB entry 7uhy, assembly 1, side view.
GATOR2 complex protein WDR24 in PDB entry 7uhy, assembly 1, top view.
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GATOR2 complex protein WDR59
Chain: D
Length: 974 amino acids
Theoretical weight: 109.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PJI9 (Residues: 1-974; Coverage: 100%)
Gene names: FP977, KIAA1923, WDR59
Pfam:
InterPro:
GATOR2 complex protein WDR59 in PDB entry 7uhy, assembly 1, front view.
GATOR2 complex protein WDR59 in PDB entry 7uhy, assembly 1, side view.
GATOR2 complex protein WDR59 in PDB entry 7uhy, assembly 1, top view.
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Nucleoporin SEH1
Chains: E, F, G
Length: 421 amino acids
Theoretical weight: 46.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96EE3 (Residues: 1-357; Coverage: 99%)
  • Best match: Q96EE3-1 (Residues: 1-421)
Gene names: SEC13L, SEH1, SEH1L
Pfam: WD domain, G-beta repeat
InterPro:
Nucleoporin SEH1 in PDB entry 7uhy, assembly 1, front view.
Nucleoporin SEH1 in PDB entry 7uhy, assembly 1, side view.
Nucleoporin SEH1 in PDB entry 7uhy, assembly 1, top view.
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Protein SEC13 homolog
Chain: H
Length: 322 amino acids
Theoretical weight: 35.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55735 (Residues: 1-322; Coverage: 100%)
Gene names: D3S1231E, SEC13, SEC13A, SEC13L1, SEC13R
Pfam: WD domain, G-beta repeat
InterPro:
Protein SEC13 homolog in PDB entry 7uhy, assembly 1, front view.
Protein SEC13 homolog in PDB entry 7uhy, assembly 1, side view.
Protein SEC13 homolog in PDB entry 7uhy, assembly 1, top view.
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Unknown
Chain: I
Length: 15 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Unknown in PDB entry 7uhy, assembly 1, front view.
Unknown in PDB entry 7uhy, assembly 1, side view.
Unknown in PDB entry 7uhy, assembly 1, top view.
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Unknown
Chain: J
Length: 8 amino acids
Theoretical weight: 699 Da
Source organism: Homo sapiens
Expression system: Homo sapiens
Unknown in PDB entry 7uhy, assembly 1, front view.
Unknown in PDB entry 7uhy, assembly 1, side view.
Unknown in PDB entry 7uhy, assembly 1, top view.
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