7uot

Electron Microscopy
2.77Å resolution

Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-530774 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (14 distinct):
Glycoprotein G1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 259 amino acids
Theoretical weight: 29.06 KDa
Source organism: Lassa virus Josiah
Expression system: Homo sapiens
UniProt:
  • Canonical: P08669 (Residues: 1-259; Coverage: 53%)
Gene names: GP-C, GPC
Sequence domains: Arenavirus glycoprotein
Glycoprotein G2 Chains: a, b, c
Molecule details ›
Chains: a, b, c
Length: 232 amino acids
Theoretical weight: 26.8 KDa
Source organism: Lassa virus Josiah
Expression system: Homo sapiens
UniProt:
  • Canonical: P08669 (Residues: 260-491; Coverage: 47%)
Gene names: GP-C, GPC
Sequence domains: Arenavirus glycoprotein
37.2D light chain (variable domain) Chains: P, R, T
Molecule details ›
Chains: P, R, T
Length: 105 amino acids
Theoretical weight: 11.41 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
37.2D heavy chain (variable domain) Chains: O, Q, S
Molecule details ›
Chains: O, Q, S
Length: 126 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
8.9F heavy chain (variable domain) Chain: H
Molecule details ›
Chain: H
Length: 136 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
8.9F light chain (variable domain) Chain: L
Molecule details ›
Chain: L
Length: 109 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, FUC, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, FUC
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.77Å
Relevant EMDB volumes: EMD-26653
Expression systems:
  • Homo sapiens
  • Drosophila melanogaster