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Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D

Electron Microscopy
2.77Å resolution
PDB entry 7uot coloured by chain, front view.
PDB entry 7uot coloured by chain, side view.
PDB entry 7uot coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetradecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycoprotein G1 and IG-light kappa chain and IG-heavy chain and IG-heavy chain and IG-light lambda chain
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Multimeric state: hetero tetradecamer
Accessible surface area: 83120.49 Å2
Buried surface area: 73425.84 Å2
Dissociation area: 1,805.95 Å2
Dissociation energy (ΔGdiss): -12.62 kcal/mol
Dissociation entropy (TΔSdiss): 13.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-530774

Macromolecules

Glycoprotein G1
Chains: A, B, C
Length: 259 amino acids
Theoretical weight: 29.06 KDa
Source organism: Lassa virus Josiah
Expression system: Homo sapiens
UniProt:
  • Canonical: P08669 (Residues: 1-259; Coverage: 53%)
Gene names: GP-C, GPC
Pfam: Arenavirus glycoprotein
InterPro: Arenavirus glycoprotein
Glycoprotein G1 in PDB entry 7uot, assembly 1, front view.
Glycoprotein G1 in PDB entry 7uot, assembly 1, side view.
Glycoprotein G1 in PDB entry 7uot, assembly 1, top view.
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Glycoprotein G2
Chains: a, b, c
Length: 232 amino acids
Theoretical weight: 26.8 KDa
Source organism: Lassa virus Josiah
Expression system: Homo sapiens
UniProt:
  • Canonical: P08669 (Residues: 260-491; Coverage: 47%)
Gene names: GP-C, GPC
Pfam: Arenavirus glycoprotein
InterPro:
Glycoprotein G2 in PDB entry 7uot, assembly 1, front view.
Glycoprotein G2 in PDB entry 7uot, assembly 1, side view.
Glycoprotein G2 in PDB entry 7uot, assembly 1, top view.
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37.2D light chain (variable domain)
Chains: P, R, T
Length: 105 amino acids
Theoretical weight: 11.41 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
InterPro:
37.2D light chain (variable domain) in PDB entry 7uot, assembly 1, front view.
37.2D light chain (variable domain) in PDB entry 7uot, assembly 1, side view.
37.2D light chain (variable domain) in PDB entry 7uot, assembly 1, top view.
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37.2D heavy chain (variable domain)
Chains: O, Q, S
Length: 126 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
InterPro:
37.2D heavy chain (variable domain) in PDB entry 7uot, assembly 1, front view.
37.2D heavy chain (variable domain) in PDB entry 7uot, assembly 1, side view.
37.2D heavy chain (variable domain) in PDB entry 7uot, assembly 1, top view.
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8.9F heavy chain (variable domain)
Chain: H
Length: 136 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
InterPro:
8.9F heavy chain (variable domain) in PDB entry 7uot, assembly 1, front view.
8.9F heavy chain (variable domain) in PDB entry 7uot, assembly 1, side view.
8.9F heavy chain (variable domain) in PDB entry 7uot, assembly 1, top view.
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8.9F light chain (variable domain)
Chain: L
Length: 109 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
InterPro:
8.9F light chain (variable domain) in PDB entry 7uot, assembly 1, front view.
8.9F light chain (variable domain) in PDB entry 7uot, assembly 1, side view.
8.9F light chain (variable domain) in PDB entry 7uot, assembly 1, top view.
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