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Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D

Electron Microscopy
2.77Å resolution
PDB entry 7uot coloured by chain, front view.
PDB entry 7uot coloured by chain, side view.
PDB entry 7uot coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetradecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycoprotein G1 and IG-light kappa chain and IG-heavy chain and IG-heavy chain and IG-light lambda chain
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Multimeric state: hetero tetradecamer
Accessible surface area: 83120.49 Å2
Buried surface area: 73425.84 Å2
Dissociation area: 1,805.95 Å2
Dissociation energy (ΔGdiss): -12.62 kcal/mol
Dissociation entropy (TΔSdiss): 13.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-279557

Macromolecules

Glycoprotein G1
Chains: A, B, C
Length: 259 amino acids
Theoretical weight: 29.06 KDa
Source organism: Lassa virus Josiah
Expression system: Homo sapiens
Glycoprotein G1 in PDB entry 7uot, assembly 1, front view.
Glycoprotein G1 in PDB entry 7uot, assembly 1, side view.
Glycoprotein G1 in PDB entry 7uot, assembly 1, top view.
125920406080100120140160180200220240
 
100200MGQIVTFFQEVPHVIEEVMNIVLIALSVLAVLKGLYNFATCGLVGLVTFLLLCGRSCTTSLYKGVYELQTLELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTFHLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNWDCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLGLLSQRTRDIYISRRLL
UniProt
P08669
PRO_0000353854
PRO_0000353855
PRO_0000036601
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
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Glycoprotein G2
Chains: a, b, c
Length: 232 amino acids
Theoretical weight: 26.8 KDa
Source organism: Lassa virus Josiah
Expression system: Homo sapiens
Glycoprotein G2 in PDB entry 7uot, assembly 1, front view.
Glycoprotein G2 in PDB entry 7uot, assembly 1, side view.
Glycoprotein G2 in PDB entry 7uot, assembly 1, top view.
123220406080100120140160180200220
 
100200GTFTWTLSDSEGKDTPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAEAQTSIQLINKAVNALINDQLIMKNHLRDIMGIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMERQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKSCPKPHRLNHMGICSCGLYKQPGVPVKWKR
UniProt
P08669
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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37.2D light chain (variable domain)
Chains: P, R, T
Length: 105 amino acids
Theoretical weight: 11.41 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
37.2D light chain (variable domain) in PDB entry 7uot, assembly 1, front view.
37.2D light chain (variable domain) in PDB entry 7uot, assembly 1, side view.
37.2D light chain (variable domain) in PDB entry 7uot, assembly 1, top view.
1105102030405060708090100
 
50100ETTLTQSPATLSVSPGETATLSCRASQNVINNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSMQSEDFAVYYCQQYNDWPRSFGQGTRLD
Chains
Chain C (auth T)
Chain G (auth P)
Chain K (auth R)
Domains
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37.2D heavy chain (variable domain)
Chains: O, Q, S
Length: 126 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
37.2D heavy chain (variable domain) in PDB entry 7uot, assembly 1, front view.
37.2D heavy chain (variable domain) in PDB entry 7uot, assembly 1, side view.
37.2D heavy chain (variable domain) in PDB entry 7uot, assembly 1, top view.
1126102030405060708090100110120
 
50100EVQLVQSGAEVKKPGASVKVSCKASGYTFTKYGISWVRQAPGQGLEWMGWISAFNGYTRYGQRFQGKVTMTTDTSTNTASLEVRTLTSNDTAVYYCARQYPDQYSSSGWPRLFAMDVWGQGTTVTV
Chains
Chain D (auth S)
Chain H (auth O)
Chain L (auth Q)
Domains
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8.9F heavy chain (variable domain)
Chain: H
Length: 136 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
8.9F heavy chain (variable domain) in PDB entry 7uot, assembly 1, front view.
8.9F heavy chain (variable domain) in PDB entry 7uot, assembly 1, side view.
8.9F heavy chain (variable domain) in PDB entry 7uot, assembly 1, top view.
1136102030405060708090100110120130
 
50100QGTLRESGPGLVRPSETLSLTCGVSGYSISSGYYWGWIRQPPGKGLEWIGNIYRSGSTYYNPSLKSRVTVSIDTSKNQFSLKLNSVTAADTAVYYCARSGIKVADDYYYEMDVWGQGTDDYSYAMDVWGQGTTVTV
Chains
Chain M (auth H)
Domains
Secondary structure
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8.9F light chain (variable domain)
Chain: L
Length: 109 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
8.9F light chain (variable domain) in PDB entry 7uot, assembly 1, front view.
8.9F light chain (variable domain) in PDB entry 7uot, assembly 1, side view.
8.9F light chain (variable domain) in PDB entry 7uot, assembly 1, top view.
1109102030405060708090100
 
50100QAVLTQPASVSGSPGQSITISCTAANSDIGDFAFVSWYQQRPDKAPKLMVYEVSSRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCTSYTSSSTFVFGTGTKVTV
Chains
Chain N (auth L)
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
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