Function and Biology Details
Reactions catalysed:
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
EXT1-EXT2 heparan sulfate biosynthesis complex (preferred)
PDBe Complex ID:
PDB-CPX-172463 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Exostosin-1
Molecule details ›
Chain: A
Length: 720 amino acids
Theoretical weight: 83.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 720 amino acids
Theoretical weight: 83.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q16394 (Residues: 28-746; Coverage: 96%)
Sequence domains:
Exostosin-2
Molecule details ›
Chain: B
Length: 674 amino acids
Theoretical weight: 77.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 674 amino acids
Theoretical weight: 77.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q93063 (Residues: 46-718; Coverage: 94%)
Sequence domains:
