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Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with UDP-GlcNAc

Electron Microscopy
3.3Å resolution
PDB entry 7uqx coloured by chain, front view.
PDB entry 7uqx coloured by chain, side view.
PDB entry 7uqx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: EXT1-EXT2 heparan sulfate biosynthesis complex
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Multimeric state: hetero dimer
Accessible surface area: 46601.86 Å2
Buried surface area: 9667.71 Å2
Dissociation area: 3,513.08 Å2
Dissociation energy (ΔGdiss): 39.2 kcal/mol
Dissociation entropy (TΔSdiss): 15.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172463

Macromolecules

Exostosin-1
Chain: A
Length: 720 amino acids
Theoretical weight: 83.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16394 (Residues: 28-746; Coverage: 96%)
Gene name: EXT1
Pfam:
InterPro:
Exostosin-1 in PDB entry 7uqx, assembly 1, front view.
Exostosin-1 in PDB entry 7uqx, assembly 1, side view.
Exostosin-1 in PDB entry 7uqx, assembly 1, top view.
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Exostosin-2
Chain: B
Length: 674 amino acids
Theoretical weight: 77.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q93063 (Residues: 46-718; Coverage: 94%)
Gene name: EXT2
Pfam:
InterPro:
Exostosin-2 in PDB entry 7uqx, assembly 1, front view.
Exostosin-2 in PDB entry 7uqx, assembly 1, side view.
Exostosin-2 in PDB entry 7uqx, assembly 1, top view.
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