› 7urn

Electron Microscopy
3.43Å resolution

Structure of HIV-1 capsid declination

Released:
DOI: 10.2210/pdb7urn/pdb
PDB entry 7urn coloured by chain, front view.
PDB entry 7urn coloured by chain, side view.
PDB entry 7urn coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
A molecular switch modulates assembly and host factor binding of the HIV-1 capsid.
Schirra RT, Dos Santos NFB, Zadrozny KK, Kucharska I, Ganser-Pornillos BK, Pornillos O
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 36759579
Related structures: EMD-26715

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 35-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146188 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chains: A, L, M, N, O, P, Q
Molecule details ›
Chains: A, L, M, N, O, P, Q
Length: 231 amino acids
Theoretical weight: 25.63 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand IHP 2 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.43Å
Relevant EMDB volumes: EMD-26715
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Highlights on the Development, Related Patents, and Prospects of Lenacapavir: The First-in-Class HIV-1 Capsid Inhibitor for the Treatment of Multi-Drug-Resistant HIV-1 Infection.
Dzinamarira et al. (2023)
1 more

2 mentions without citation

A molecular switch modulates assembly and host factor binding of the HIV-1 capsid.
Schirra et al. (2023)
1 more