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The 1.67 Angstrom CryoEM structure of the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis - catalytic dimer (Huc2S2L)

Source organism: Mycolicibacterium smegmatis MC2 155
Biochemical function: metal ion binding
Biological process: anaerobic respiration
Cellular component: [Ni-Fe] hydrogenase complex

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EC 1.12.99.6: Hydrogenase (acceptor)

Reaction catalysed:
H(2) + A = AH(2)
Systematic name:
Hydrogen:acceptor oxidoreductase
Alternative Name(s):
  • H(2) producing hydrogenase
  • Hydrogen-lyase
  • Hydrogen:(acceptor) oxidoreductase
  • Hydrogenlyase
  • Uptake hydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00374
Domain description: Nickel-dependent hydrogenase
Occurring in:
  1. Hydrogenase-2, large subunit
The deposited structure of PDB entry 7uur contains 4 copies of Pfam domain PF00374 (Nickel-dependent hydrogenase) in Hydrogenase-2, large subunit. Showing 2 copies in chain A [auth C].

PF14720
Domain description: NiFe/NiFeSe hydrogenase small subunit C-terminal
Occurring in:
  1. Hydrogenase-2, small subunit
The deposited structure of PDB entry 7uur contains 2 copies of Pfam domain PF14720 (NiFe/NiFeSe hydrogenase small subunit C-terminal) in NADH ubiquinone oxidoreductase 20 kDa subunit. Showing 1 copy in chain B [auth D].

PF01058
Domain description: NADH ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. Hydrogenase-2, small subunit
The deposited structure of PDB entry 7uur contains 2 copies of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in NADH ubiquinone oxidoreductase 20 kDa subunit. Showing 1 copy in chain B [auth D].

InterPro InterPro annotations
IPR001821
Domain description: [NiFe]-hydrogenase, small subunit
Occurring in:
  1. Hydrogenase-2, small subunit
IPR001501
Domain description: Nickel-dependent hydrogenase, large subunit
Occurring in:
  1. Hydrogenase-2, large subunit
IPR029014
Domain description: [NiFe]-hydrogenase, large subunit
Occurring in:
  1. Hydrogenase-2, large subunit
IPR027394
Domain description: Cytochrome-c3 hydrogenase, C-terminal
Occurring in:
  1. Hydrogenase-2, small subunit
IPR037148
Domain description: [NiFe]-hydrogenase, small subunit, C-terminal domain superfamily
Occurring in:
  1. Hydrogenase-2, small subunit
IPR006137
Domain description: NADH:ubiquinone oxidoreductase-like, 20kDa subunit
Occurring in:
  1. Hydrogenase-2, small subunit
IPR037024
Domain description: [NiFe]-hydrogenase, small subunit, N-terminal domain superfamily
Occurring in:
  1. Hydrogenase-2, small subunit
IPR018194
Domain description: Nickel-dependent hydrogenase, large subunit, nickel binding site
Occurring in:
  1. Hydrogenase-2, large subunit

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