› 7v6y

Electron Microscopy
3.5Å resolution

Cryo-EM structure of Patched in lipid nanodisc - the wildtype, 3.5 angstrom (re-processed with dataset of 7dzq)

Released:
DOI: 10.2210/pdb7v6y/pdb
PDB entry 7v6y coloured by chain, front view.
PDB entry 7v6y coloured by chain, side view.
PDB entry 7v6y coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
Luo Y, Wan G, Zhang X, Zhou X, Wang Q, Fan J, Cai H, Ma L, Wu H, Qu Q, Cong Y, Zhao Y, Li D
Structure 29 1286-1294.e6 (2021)
PMID: 34174188
Related structures: EMD-31753

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178858 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protein patched homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 1090 amino acids
Theoretical weight: 121.64 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q61115 (Residues: 2-1175; Coverage: 75%)
Gene names: Ptch, Ptch1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand CLR 2 x CLR
Ligand 5VI 1 x 5VI
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-31753
Expression system: Homo sapiens

Quick links

Citations

1 review citation

The lipid rafts in cancer stem cell: a target to eradicate cancer.
Zhang et al. (2022)
3 other articles