7vad

Electron Microscopy
3.41Å resolution

Cryo-EM structure of human NTCP complexed with YN69202Fab

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-278772 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hepatic sodium/bile acid cotransporter Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14973 (Residues: 1-319; Coverage: 91%)
Gene names: GIG29, NTCP, SLC10A1
Sequence domains: Sodium Bile acid symporter family
Fab heavy chain from antibody IgG clone number YN69202 Chain: H
Molecule details ›
Chain: H
Length: 249 amino acids
Theoretical weight: 26.57 KDa
Source organism: Ondatra zibethicus
Expression system: Spodoptera frugiperda
Fab light chain from antibody IgG clone number YN69202 Chain: L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.41Å
Relevant EMDB volumes: EMD-31837
Expression system: Spodoptera frugiperda