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Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome.

<div class='caption-title'>Overall structure of the PBS core from T. vulcanus.</div>
<div class='caption-title'>Structures of A, B, and C cylinders, including terminal emitters and linker proteins.</div>
<div class='caption-title'>Arrangement of chromophores is the key to the energy transfer pathway in PBS core.</div>
Kawakami K, Hamaguchi T, Hirose Y, Kosumi D, Miyata M, Kamiya N, Yonekura K
OpenAccess logo Nat Commun 13 3389 (2022)
Cited: 9 times
EuropePMC logo PMID: 35715389

Abstract

Cyanobacteria, glaucophytes, and rhodophytes utilize giant, light-harvesting phycobilisomes (PBSs) for capturing solar energy and conveying it to photosynthetic reaction centers. PBSs are compositionally and structurally diverse, and exceedingly complex, all of which pose a challenge for a comprehensive understanding of their function. To date, three detailed architectures of PBSs by cryo-electron microscopy (cryo-EM) have been described: a hemiellipsoidal type, a block-type from rhodophytes, and a cyanobacterial hemidiscoidal-type. Here, we report cryo-EM structures of a pentacylindrical allophycocyanin core and phycocyanin-containing rod of a thermophilic cyanobacterial hemidiscoidal PBS. The structures define the spatial arrangement of protein subunits and chromophores, crucial for deciphering the energy transfer mechanism. They reveal how the pentacylindrical core is formed, identify key interactions between linker proteins and the bilin chromophores, and indicate pathways for unidirectional energy transfer.

Articles - 7vea mentioned but not cited (1)

  1. Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome. Kawakami K, Hamaguchi T, Hirose Y, Kosumi D, Miyata M, Kamiya N, Yonekura K. Nat Commun 13 3389 (2022)


Reviews citing this publication (2)

  1. The increasing role of structural proteomics in cyanobacteria. Sound JK, Bellamy-Carter J, Leney AC. Essays Biochem 67 269-282 (2023)
  2. The Unique Light-Harvesting System of the Algal Phycobilisome: Structure, Assembly Components, and Functions. Li X, Hou W, Lei J, Chen H, Wang Q. Int J Mol Sci 24 9733 (2023)

Articles citing this publication (6)

  1. A hybrid type of chromatic acclimation regulated by the dual green/red photosensory systems in cyanobacteria. Otsu T, Eki T, Hirose Y. Plant Physiol 190 779-793 (2022)
  2. A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Jiang HW, Wu HY, Wang CH, Yang CH, Ko JT, Ho HC, Tsai MD, Bryant DA, Li FW, Ho MC, Ho MY. Nat Commun 14 8009 (2023)
  3. Antenna Modification in a Fast-Growing Cyanobacterium Synechococcus elongatus UTEX 2973 Leads to Improved Efficiency and Carbon-Neutral Productivity. Sengupta A, Bandyopadhyay A, Schubert MG, Church GM, Pakrasi HB. Microbiol Spectr 11 e0050023 (2023)
  4. Cryo-EM and femtosecond spectroscopic studies provide mechanistic insight into the energy transfer in CpcL-phycobilisomes. Zheng L, Zhang Z, Wang H, Zheng Z, Wang J, Liu H, Chen H, Dong C, Wang G, Weng Y, Gao N, Zhao J. Nat Commun 14 3961 (2023)
  5. Phycobilisome's Exciton Transfer Efficiency Relies on an Energetic Funnel Driven by Chromophore-Linker Protein Interactions. Sohoni S, Lloyd LT, Hitchcock A, MacGregor-Chatwin C, Iwanicki A, Ghosh I, Shen Q, Hunter CN, Engel GS. J Am Chem Soc 145 11659-11668 (2023)
  6. Redshifting and Blueshifting of β82 Chromophores in the Phycocyanin Hexamer of Porphyridium purpureum Phycobilisomes Due to Linker Proteins. Kikuchi H. Life (Basel) 12 1833 (2022)


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