7vgx

Electron Microscopy
3.2Å resolution

Neuropeptide Y Y1 Receptor (NPY1R) in Complex with G Protein and its endogeneous Peptide-Agonist Neuropeptide Y (NPY)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-208392 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Neuropeptide Y receptor type 1 Chain: R
Molecule details ›
Chain: R
Length: 402 amino acids
Theoretical weight: 46.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P25929 (Residues: 1-384; Coverage: 100%)
Gene names: NPY1R, NPYR, NPYY1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Neuropeptide Y Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01303 (Residues: 29-64; Coverage: 52%)
Gene name: NPY
Sequence domains: Pancreatic hormone peptide
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
single-chain antibody Fv fragment (scFv16) Chain: S

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-31979
Expression systems:
  • Spodoptera frugiperda
  • Not provided
  • Escherichia coli
  • Trichoplusia ni