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Crystal structure of EP300 HAT domain in complex with compound 7

Source organism: Homo sapiens
Biochemical function: histone acetyltransferase activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08214
Domain description: Histone acetylation protein
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 7vhz contains 2 copies of Pfam domain PF08214 (Histone acetylation protein) in Histone acetyltransferase p300. Showing 1 copy in chain A.

PF06001
Domain description: CREB-binding protein/p300, atypical RING domain
Occurring in:
  1. Histone acetyltransferase p300
The deposited structure of PDB entry 7vhz contains 2 copies of Pfam domain PF06001 (CREB-binding protein/p300, atypical RING domain) in Histone acetyltransferase p300. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013178
Domain description: Histone acetyltransferase Rtt109/CBP
Occurring in:
  1. Histone acetyltransferase p300
IPR010303
Domain description: CREB-binding protein/p300, atypical RING domain
Occurring in:
  1. Histone acetyltransferase p300
IPR031162
Domain description: CBP/p300-type histone acetyltransferase domain
Occurring in:
  1. Histone acetyltransferase p300
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. Histone acetyltransferase p300
IPR038547
Domain description: CBP/p300, atypical RING domain superfamily
Occurring in:
  1. Histone acetyltransferase p300

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