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Crystal structure of EP300 HAT domain in complex with compound 7

X-ray diffraction
2Å resolution
PDB entry 7vhz coloured by chain, front view.
PDB entry 7vhz coloured by chain, side view.
PDB entry 7vhz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone acetyltransferase p300
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Multimeric state: monomeric
Accessible surface area: 21703.0 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170794
Assembly 2
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Assembly Name: Histone acetyltransferase p300
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Multimeric state: monomeric
Accessible surface area: 21681.35 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170794

Macromolecules

Histone acetyltransferase p300
Chains: A, B
Length: 454 amino acids
Theoretical weight: 52.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q09472 (Residues: 1159-1519, 1581-1666; Coverage: 19%)
Gene names: EP300, P300
Pfam:
InterPro:
Histone acetyltransferase p300 in PDB entry 7vhz, assembly 1, front view.
Histone acetyltransferase p300 in PDB entry 7vhz, assembly 1, side view.
Histone acetyltransferase p300 in PDB entry 7vhz, assembly 1, top view.
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