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Crystal structure of TrkA (G595R) kinase with repotrectinib

X-ray diffraction
2.7Å resolution
PDB entry 7vkn coloured by chain, front view.
PDB entry 7vkn coloured by chain, side view.
PDB entry 7vkn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: High affinity nerve growth factor receptor
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Multimeric state: monomeric
Accessible surface area: 14960.44 Å2
Buried surface area: 919.81 Å2
Dissociation area: 74.3 Å2
Dissociation energy (ΔGdiss): 10.64 kcal/mol
Dissociation entropy (TΔSdiss): 0.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138088

Macromolecules

High affinity nerve growth factor receptor
Chain: A
Length: 326 amino acids
Theoretical weight: 37.34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04629 (Residues: 502-796; Coverage: 39%)
Gene names: MTC, NTRK1, TRK, TRKA
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
High affinity nerve growth factor receptor in PDB entry 7vkn, assembly 1, front view.
High affinity nerve growth factor receptor in PDB entry 7vkn, assembly 1, side view.
High affinity nerve growth factor receptor in PDB entry 7vkn, assembly 1, top view.
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