› 7vwc

Electron Microscopy
3.53Å resolution

Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1

Released:
DOI: 10.2210/pdb7vwc/pdb
PDB entry 7vwc coloured by chain, front view.
PDB entry 7vwc coloured by chain, side view.
PDB entry 7vwc coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ, Hou WT, Chen Y
Nat Commun 13 3299 (2022)
PMID: 35676282
Related structures: EMD-32152

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ABC transporter domain-containing protein; ATP-binding cassette sub-family D member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 789 amino acids
Theoretical weight: 87.93 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: O45730 (Residues: 2-66; Coverage: 9%)
  • Canonical: P33897 (Residues: 65-745; Coverage: 91%)
Gene names: ABCD1, ALD, CELE_T02D1.5, T02D1.5, pmp-4
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 82T 2 x 82T
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.53Å
Relevant EMDB volumes: EMD-32152
Expression system: Homo sapiens

Quick links

Citations

2 review citations

The peroxisome: an update on mysteries 3.0.
Kumar et al. (2024)
1 more