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Cryo-EM structure of a dimeric GPCR-Gi complex with peptide

Electron Microscopy
4.21Å resolution
PDB entry 7w0n coloured by chain, front view.
PDB entry 7w0n coloured by chain, side view.
PDB entry 7w0n coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 79136.94 Å2
Buried surface area: 12549.14 Å2
Dissociation area: 2,772.7 Å2
Dissociation energy (ΔGdiss): -20.44 kcal/mol
Dissociation entropy (TΔSdiss): 55.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225127

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-1
Chain: A
Length: 356 amino acids
Theoretical weight: 40.56 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 7w0n, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 7w0n, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 7w0n, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7w0n, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7w0n, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7w0n, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7w0n, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7w0n, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7w0n, assembly 1, top view.
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Apelin receptor; Soluble cytochrome b562
Chains: Q, R
Length: 477 amino acids
Theoretical weight: 54.31 KDa
Source organisms: Expression system: Trichoplusia ni
UniProt:
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
  • Canonical: P35414 (Residues: 2-330; Coverage: 87%)
    • nullnull
Gene names: AGTRL1, APJ, APLNR, cybC
Pfam:
InterPro:
Apelin receptor in PDB entry 7w0n, assembly 1, front view.
Apelin receptor in PDB entry 7w0n, assembly 1, side view.
Apelin receptor in PDB entry 7w0n, assembly 1, top view.
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scFv16
Chain: S
Length: 297 amino acids
Theoretical weight: 31.87 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
InterPro:
scFv16 in PDB entry 7w0n, assembly 1, front view.
scFv16 in PDB entry 7w0n, assembly 1, side view.
scFv16 in PDB entry 7w0n, assembly 1, top view.
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Apelin receptor early endogenous ligand
Chains: D, E
Length: 32 amino acids
Theoretical weight: 3.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P0DMC3 (Residues: 23-54; Coverage: 100%)
Gene names: APELA, ELA, TDL
Pfam: Apelin receptor early endogenous ligand
InterPro: Apelin receptor early endogenous ligand
Apelin receptor early endogenous ligand in PDB entry 7w0n, assembly 1, front view.
Apelin receptor early endogenous ligand in PDB entry 7w0n, assembly 1, side view.
Apelin receptor early endogenous ligand in PDB entry 7w0n, assembly 1, top view.
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