EC 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating)
Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Systematic name:
NADH:ubiquinone oxidoreductase
Alternative Name(s):
- Coenzyme Q reductase
- Complex 1 dehydrogenase
- Complex I (NADH:Q1 oxidoreductase)
- Complex I (electron transport chain)
- Complex I (mitochondrial electron transport)
- DPNH-coenzyme Q reductase
- DPNH-ubiquinone reductase
- Dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
- Electron transfer complex I
- Mitochondrial electron transport complex 1
- Mitochondrial electron transport complex I
- NADH coenzyme Q1 reductase
- NADH dehydrogenase (ubiquinone)
- NADH-CoQ oxidoreductase
- NADH-CoQ reductase
- NADH-Q6 oxidoreductase
- NADH-coenzyme Q oxidoreductase
- NADH-coenzyme Q reductase
- NADH-ubiquinone oxidoreductase
- NADH-ubiquinone reductase
- NADH-ubiquinone-1 reductase
- NADH:ubiquinone oxidoreductase complex
- Reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
- Type 1 dehydrogenase
- Ubiquinone reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF00662
Domain description:
NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>7w32</span> contains 1 copy of Pfam domain <span class='highlight'>PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus)</span> in <span class='highlight'>NADH-ubiquinone oxidoreductase chain 5</span>. Showing 1 copy in chain <span class='highlight'>JA [auth l]</span>. The deposited structure of PDB entry 7w32 contains 1 copy of Pfam domain PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus) in NADH-ubiquinone oxidoreductase chain 5. Showing 1 copy in chain JA [auth l].](https://www.ebi.ac.uk/pdbe/static/entry/7w32_35_l_Pfam_PF00662_image-200x200.png)
PF15088
Domain description:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>7w32</span> contains 1 copy of Pfam domain <span class='highlight'>PF15088 (NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial)</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>DA [auth f]</span>. The deposited structure of PDB entry 7w32 contains 1 copy of Pfam domain PF15088 (NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial) in NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial. Showing 1 copy in chain DA [auth f].](https://www.ebi.ac.uk/pdbe/static/entry/7w32_29_f_Pfam_PF15088_image-200x200.png)
PF10183
Domain description:
ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>7w32</span> contains 1 copy of Pfam domain <span class='highlight'>PF10183 (ESSS subunit of NADH:ubiquinone oxidoreductase (complex I))</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>CA [auth e]</span>. The deposited structure of PDB entry 7w32 contains 1 copy of Pfam domain PF10183 (ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)) in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial. Showing 1 copy in chain CA [auth e].](https://www.ebi.ac.uk/pdbe/static/entry/7w32_28_e_Pfam_PF10183_image-200x200.png)
PF05821
Domain description:
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>7w32</span> contains 1 copy of Pfam domain <span class='highlight'>PF05821 (NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8))</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>AA [auth c]</span>. The deposited structure of PDB entry 7w32 contains 1 copy of Pfam domain PF05821 (NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)) in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial. Showing 1 copy in chain AA [auth c].](https://www.ebi.ac.uk/pdbe/static/entry/7w32_26_c_Pfam_PF05821_image-200x200.png)
PF22151
Domain description:
NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain
Occurring in:
Occurring in:
PF22117
Domain description:
NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain
Occurring in:
Occurring in:
PF10588
Domain description:
NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>7w32</span> contains 1 copy of Pfam domain <span class='highlight'>PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region)</span> in <span class='highlight'>NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>L [auth M]</span>. The deposited structure of PDB entry 7w32 contains 1 copy of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain L [auth M].](https://www.ebi.ac.uk/pdbe/static/entry/7w32_12_M_Pfam_PF10588_image-200x200.png)
PF15880
Domain description:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Occurring in:
Occurring in:
PF07347
Domain description:
NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Occurring in:
Occurring in:
PF10589
Domain description:
NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>7w32</span> contains 1 copy of Pfam domain <span class='highlight'>PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region)</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 7w32 contains 1 copy of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/7w32_1_A_Pfam_PF10589_image-200x200.png)
InterPro annotations
IPR001694
Domain description:
NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H
Occurring in:
Occurring in:
IPR001750
Domain description:
NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
Occurring in:
Occurring in:
IPR017384
Domain description:
NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1
Occurring in:
Occurring in:
IPR019574
Domain description:
NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Occurring in:
Occurring in:
IPR000283
Domain description:
NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Occurring in:
Occurring in:
IPR015828
Domain description:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Occurring in:
Occurring in:
IPR008698
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7
Occurring in:
Occurring in:
IPR016680
Domain description:
NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8
Occurring in:
Occurring in:
IPR018086
Domain description:
NADH:ubiquinone oxidoreductase, subunit 1, conserved site
Occurring in:
Occurring in:
IPR012576
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Occurring in:
Occurring in:
IPR026627
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, animal type
Occurring in:
Occurring in:
IPR026626
Domain description:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Occurring in:
Occurring in:
IPR037232
Domain description:
NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily
Occurring in:
Occurring in:
IPR007763
Domain description:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Occurring in:
Occurring in:
IPR006885
Domain description:
NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like
Occurring in:
Occurring in:
IPR009947
Domain description:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Occurring in:
Occurring in:
IPR006806
Domain description:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Occurring in:
Occurring in:
IPR016464
Domain description:
NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2
Occurring in:
Occurring in:
IPR016488
Domain description:
NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6
Occurring in:
Occurring in:
IPR019575
Domain description:
NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Occurring in:
Occurring in:
IPR037207
Domain description:
NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Occurring in:
Occurring in:
IPR001949
Domain description:
NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Occurring in:
Occurring in:
IPR037225
Domain description:
NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
Occurring in:
Occurring in:
IPR033034
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Occurring in:
Occurring in:
IPR012575
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1
Occurring in:
Occurring in:
IPR042106
Domain description:
NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
Occurring in:
Occurring in:
IPR001516
Domain description:
NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal
Occurring in:
Occurring in:
IPR039428
Domain description:
NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like
Occurring in:
Occurring in:
IPR039993
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Occurring in:
Occurring in:
IPR016551
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa
Occurring in:
Occurring in:
IPR008699
Domain description:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8
Occurring in:
Occurring in:
IPR039205
Domain description:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Occurring in:
Occurring in:
IPR016668
Domain description:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Occurring in:
Occurring in:
IPR014029
Domain description:
NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site
Occurring in:
Occurring in:
IPR020396
Domain description:
NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
Occurring in:
Occurring in:
IPR015405
Domain description:
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like
Occurring in:
Occurring in:
IPR038532
Domain description:
NADH dehydrogenase ubiquinone Fe-S protein 4-like superfamily
Occurring in:
Occurring in:
IPR011538
Domain description:
NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Occurring in:
Occurring in: