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The cryo-EM structure of human pre-C*-II complex

Electron Microscopy
3.6Å resolution
PDB entry 7w5a coloured by chain, front view.
PDB entry 7w5a coloured by chain, side view.
PDB entry 7w5a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 54-mer (preferred)
Entry contents: 39 distinct polypeptide molecules
5 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Exon junction core complex, MAGOH variant and RNA
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Multimeric state: hetero 54-mer
Accessible surface area: 495146.36 Å2
Buried surface area: 222460.85 Å2
Dissociation area: 2,469.94 Å2
Dissociation energy (ΔGdiss): -17.75 kcal/mol
Dissociation entropy (TΔSdiss): 35.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-249679

Macromolecules

Pre-mRNA-processing-splicing factor 8
Chain: A
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P2Q9 (Residues: 1-2335; Coverage: 100%)
Gene names: PRPC8, PRPF8
Pfam:
InterPro:
Pre-mRNA-processing-splicing factor 8 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 7w5a, assembly 1, top view.
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116 kDa U5 small nuclear ribonucleoprotein component
Chain: C
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15029 (Residues: 1-972; Coverage: 100%)
Gene names: EFTUD2, KIAA0031, SNRP116
Pfam:
InterPro:
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 7w5a, assembly 1, front view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 7w5a, assembly 1, side view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 7w5a, assembly 1, top view.
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U5 small nuclear ribonucleoprotein 40 kDa protein
Chain: E
Length: 357 amino acids
Theoretical weight: 39.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DI7 (Residues: 1-357; Coverage: 100%)
Gene names: PRP8BP, SFP38, SNRNP40, WDR57
Pfam: WD domain, G-beta repeat
InterPro:
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 7w5a, assembly 1, front view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 7w5a, assembly 1, side view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-splicing factor SYF1
Chain: I
Length: 855 amino acids
Theoretical weight: 100.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HCS7 (Residues: 1-855; Coverage: 100%)
Gene names: HCNP, KIAA1177, PP3898, SYF1, XAB2
Pfam: Tetratricopeptide repeat
InterPro:
Pre-mRNA-splicing factor SYF1 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-splicing factor SYF1 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-splicing factor SYF1 in PDB entry 7w5a, assembly 1, top view.
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Crooked neck-like protein 1
Chain: J
Length: 848 amino acids
Theoretical weight: 100.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZJ0 (Residues: 1-848; Coverage: 100%)
Gene names: CGI-201, CRN, CRNKL1, MSTP021
Pfam: HAT (Half-A-TPR) repeat
InterPro:
Crooked neck-like protein 1 in PDB entry 7w5a, assembly 1, front view.
Crooked neck-like protein 1 in PDB entry 7w5a, assembly 1, side view.
Crooked neck-like protein 1 in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-splicing factor SPF27
Chain: K
Length: 225 amino acids
Theoretical weight: 26.16 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75934 (Residues: 1-225; Coverage: 100%)
Gene names: BCAS2, DAM1
Pfam: Breast carcinoma amplified sequence 2 (BCAS2)
InterPro: Pre-mRNA-splicing factor SPF27
Pre-mRNA-splicing factor SPF27 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-splicing factor SPF27 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-splicing factor SPF27 in PDB entry 7w5a, assembly 1, top view.
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Cell division cycle 5-like protein
Chain: L
Length: 802 amino acids
Theoretical weight: 92.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99459 (Residues: 1-802; Coverage: 100%)
Gene names: CDC5L, KIAA0432, PCDC5RP
Pfam:
InterPro:
Cell division cycle 5-like protein in PDB entry 7w5a, assembly 1, front view.
Cell division cycle 5-like protein in PDB entry 7w5a, assembly 1, side view.
Cell division cycle 5-like protein in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-splicing factor SYF2
Chain: M
Length: 243 amino acids
Theoretical weight: 28.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95926 (Residues: 1-243; Coverage: 100%)
Gene names: CBPIN, GCIPIP, SYF2
Pfam: SYF2 splicing factor
InterPro: mRNA splicing factor SYF2
Pre-mRNA-splicing factor SYF2 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-splicing factor SYF2 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-splicing factor SYF2 in PDB entry 7w5a, assembly 1, top view.
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Protein BUD31 homolog
Chain: N
Length: 144 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P41223 (Residues: 1-144; Coverage: 100%)
Gene names: BUD31, EDG2
Pfam: Pre-mRNA-splicing factor BUD31
InterPro:
Protein BUD31 homolog in PDB entry 7w5a, assembly 1, front view.
Protein BUD31 homolog in PDB entry 7w5a, assembly 1, side view.
Protein BUD31 homolog in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-splicing factor RBM22
Chain: O
Length: 420 amino acids
Theoretical weight: 46.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NW64 (Residues: 1-420; Coverage: 100%)
Gene names: 199G4, RBM22, ZC3H16
Pfam:
InterPro:
Pre-mRNA-splicing factor RBM22 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-splicing factor RBM22 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-splicing factor RBM22 in PDB entry 7w5a, assembly 1, top view.
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Spliceosome-associated protein CWC15 homolog
Chain: P
Length: 229 amino acids
Theoretical weight: 26.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P013 (Residues: 1-229; Coverage: 100%)
Gene names: AD-002, C11orf5, CWC15, HSPC148
Pfam: Cwf15/Cwc15 cell cycle control protein
InterPro: Pre-mRNA-splicing factor Cwf15/Cwc15
Spliceosome-associated protein CWC15 homolog in PDB entry 7w5a, assembly 1, front view.
Spliceosome-associated protein CWC15 homolog in PDB entry 7w5a, assembly 1, side view.
Spliceosome-associated protein CWC15 homolog in PDB entry 7w5a, assembly 1, top view.
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RNA helicase aquarius
Chain: Q
Length: 1485 amino acids
Theoretical weight: 171.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60306 (Residues: 1-1485; Coverage: 100%)
Gene names: AQR, KIAA0560
Pfam:
InterPro:
RNA helicase aquarius in PDB entry 7w5a, assembly 1, front view.
RNA helicase aquarius in PDB entry 7w5a, assembly 1, side view.
RNA helicase aquarius in PDB entry 7w5a, assembly 1, top view.
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SNW domain-containing protein 1
Chain: R
Length: 536 amino acids
Theoretical weight: 61.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13573 (Residues: 1-536; Coverage: 100%)
Gene names: SKIIP, SKIP, SNW1
Pfam: SKIP/SNW domain
InterPro:
SNW domain-containing protein 1 in PDB entry 7w5a, assembly 1, front view.
SNW domain-containing protein 1 in PDB entry 7w5a, assembly 1, side view.
SNW domain-containing protein 1 in PDB entry 7w5a, assembly 1, top view.
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Peptidyl-prolyl cis-trans isomerase-like 1
Chain: S
Length: 166 amino acids
Theoretical weight: 18.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3C6 (Residues: 1-166; Coverage: 100%)
Gene names: CGI-124, CYPL1, PPIL1, UNQ2425/PRO4984
Pfam: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
InterPro:
Peptidyl-prolyl cis-trans isomerase-like 1 in PDB entry 7w5a, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase-like 1 in PDB entry 7w5a, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase-like 1 in PDB entry 7w5a, assembly 1, top view.
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Pleiotropic regulator 1
Chain: T
Length: 514 amino acids
Theoretical weight: 57.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43660 (Residues: 1-514; Coverage: 100%)
Gene name: PLRG1
Pfam: WD domain, G-beta repeat
InterPro:
Pleiotropic regulator 1 in PDB entry 7w5a, assembly 1, front view.
Pleiotropic regulator 1 in PDB entry 7w5a, assembly 1, side view.
Pleiotropic regulator 1 in PDB entry 7w5a, assembly 1, top view.
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Serine/arginine repetitive matrix protein 2
Chain: U
Length: 2752 amino acids
Theoretical weight: 300.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UQ35 (Residues: 1-2752; Coverage: 100%)
Gene names: HSPC075, KIAA0324, SRL300, SRM300, SRRM2
Pfam: cwf21 domain
InterPro:
Serine/arginine repetitive matrix protein 2 in PDB entry 7w5a, assembly 1, front view.
Serine/arginine repetitive matrix protein 2 in PDB entry 7w5a, assembly 1, side view.
Serine/arginine repetitive matrix protein 2 in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-splicing factor CWC22 homolog
Chain: V
Length: 908 amino acids
Theoretical weight: 105.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HCG8 (Residues: 1-908; Coverage: 100%)
Gene names: CWC22, KIAA1604, NCM
Pfam:
InterPro:
Pre-mRNA-splicing factor CWC22 homolog in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-splicing factor CWC22 homolog in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-splicing factor CWC22 homolog in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-processing factor 17
Chain: W
Length: 579 amino acids
Theoretical weight: 65.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60508 (Residues: 1-579; Coverage: 100%)
Gene names: CDC40, EHB3, PRP17, PRPF17
Pfam: WD domain, G-beta repeat
InterPro:
Pre-mRNA-processing factor 17 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-processing factor 17 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-processing factor 17 in PDB entry 7w5a, assembly 1, top view.
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PSME3-interacting protein
Chain: X
Length: 254 amino acids
Theoretical weight: 28.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9GZU8 (Residues: 1-254; Coverage: 100%)
Gene names: C16orf94, CDA018, CDA10, FAM192A, NIP30, PIP30, PSME3IP1
Pfam: FAM192A/Fyv6, N-terminal domain
InterPro:
PSME3-interacting protein in PDB entry 7w5a, assembly 1, front view.
PSME3-interacting protein in PDB entry 7w5a, assembly 1, side view.
PSME3-interacting protein in PDB entry 7w5a, assembly 1, top view.
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ATP-dependent RNA helicase DHX8
Chain: Y
Length: 1220 amino acids
Theoretical weight: 139.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14562 (Residues: 1-1220; Coverage: 100%)
Gene names: DDX8, DHX8
Pfam:
InterPro:
ATP-dependent RNA helicase DHX8 in PDB entry 7w5a, assembly 1, front view.
ATP-dependent RNA helicase DHX8 in PDB entry 7w5a, assembly 1, side view.
ATP-dependent RNA helicase DHX8 in PDB entry 7w5a, assembly 1, top view.
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Splicing factor Cactin
Chain: Z
Length: 758 amino acids
Theoretical weight: 88.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WUQ7 (Residues: 1-758; Coverage: 100%)
Gene names: C19orf29, CACTIN
Pfam:
InterPro:
Splicing factor Cactin in PDB entry 7w5a, assembly 1, front view.
Splicing factor Cactin in PDB entry 7w5a, assembly 1, side view.
Splicing factor Cactin in PDB entry 7w5a, assembly 1, top view.
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PRKR-interacting protein 1
Chain: 2
Length: 184 amino acids
Theoretical weight: 21.04 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H875 (Residues: 1-184; Coverage: 100%)
Gene name: PRKRIP1
Pfam: Protein of unknown function (DUF1168)
InterPro: PRKR-interacting protein 1
PRKR-interacting protein 1 in PDB entry 7w5a, assembly 1, front view.
PRKR-interacting protein 1 in PDB entry 7w5a, assembly 1, side view.
PRKR-interacting protein 1 in PDB entry 7w5a, assembly 1, top view.
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Protein FAM32A
Chain: z
Length: 112 amino acids
Theoretical weight: 13.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y421 (Residues: 1-112; Coverage: 100%)
Gene names: CGI-144, FAM32A, OTAG12
Pfam: FAM32A
InterPro: Protein FAM32A
Protein FAM32A in PDB entry 7w5a, assembly 1, front view.
Protein FAM32A in PDB entry 7w5a, assembly 1, side view.
Protein FAM32A in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein-associated proteins B and B'
Chains: b, i
Length: 240 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14678 (Residues: 1-240; Coverage: 100%)
Gene names: COD, SNRPB, SNRPB1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 7w5a, assembly 1, top view.
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Peptidyl-prolyl cis-trans isomerase E
Chain: y
Length: 301 amino acids
Theoretical weight: 33.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UNP9 (Residues: 1-301; Coverage: 100%)
Gene names: CYP33, PPIE
Pfam:
InterPro:
Peptidyl-prolyl cis-trans isomerase E in PDB entry 7w5a, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase E in PDB entry 7w5a, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase E in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D3
Chains: a, h
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62318 (Residues: 1-126; Coverage: 100%)
Gene name: SNRPD3
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D3 in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D1
Chains: c, j
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62314 (Residues: 1-119; Coverage: 100%)
Gene name: SNRPD1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D1 in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D2
Chains: d, k
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62316 (Residues: 1-118; Coverage: 100%)
Gene names: SNRPD1, SNRPD2
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D2 in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein F
Chains: f, m
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62306 (Residues: 1-86; Coverage: 100%)
Gene names: PBSCF, SNRPF
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein F in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein F in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein F in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein E
Chains: e, l
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62304 (Residues: 1-92; Coverage: 100%)
Gene name: SNRPE
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein E in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein E in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein E in PDB entry 7w5a, assembly 1, top view.
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Small nuclear ribonucleoprotein G
Chains: g, n
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62308 (Residues: 1-76; Coverage: 100%)
Gene names: PBSCG, SNRPG
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein G in PDB entry 7w5a, assembly 1, front view.
Small nuclear ribonucleoprotein G in PDB entry 7w5a, assembly 1, side view.
Small nuclear ribonucleoprotein G in PDB entry 7w5a, assembly 1, top view.
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Protein mago nashi homolog
Chain: v
Length: 146 amino acids
Theoretical weight: 17.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61326 (Residues: 1-146; Coverage: 100%)
Gene names: MAGOH, MAGOHA
Pfam: Mago nashi protein
InterPro:
Protein mago nashi homolog in PDB entry 7w5a, assembly 1, front view.
Protein mago nashi homolog in PDB entry 7w5a, assembly 1, side view.
Protein mago nashi homolog in PDB entry 7w5a, assembly 1, top view.
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RNA-binding protein 8A
Chain: w
Length: 174 amino acids
Theoretical weight: 19.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y5S9 (Residues: 1-174; Coverage: 100%)
Gene names: HSPC114, MDS014, RBM8, RBM8A
Pfam: RNA recognition motif
InterPro:
RNA-binding protein 8A in PDB entry 7w5a, assembly 1, front view.
RNA-binding protein 8A in PDB entry 7w5a, assembly 1, side view.
RNA-binding protein 8A in PDB entry 7w5a, assembly 1, top view.
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Eukaryotic initiation factor 4A-III
Chain: u
Length: 411 amino acids
Theoretical weight: 46.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P38919 (Residues: 1-411; Coverage: 100%)
Gene names: DDX48, EIF4A3, KIAA0111
Pfam:
InterPro:
Eukaryotic initiation factor 4A-III in PDB entry 7w5a, assembly 1, front view.
Eukaryotic initiation factor 4A-III in PDB entry 7w5a, assembly 1, side view.
Eukaryotic initiation factor 4A-III in PDB entry 7w5a, assembly 1, top view.
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Protein CASC3
Chain: x
Length: 703 amino acids
Theoretical weight: 76.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15234 (Residues: 1-703; Coverage: 100%)
Gene names: CASC3, MLN51
Pfam: CASC3/Barentsz eIF4AIII binding
InterPro:
Protein CASC3 in PDB entry 7w5a, assembly 1, front view.
Protein CASC3 in PDB entry 7w5a, assembly 1, side view.
Protein CASC3 in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-processing factor 19
Chains: q, r, s, t
Length: 504 amino acids
Theoretical weight: 55.25 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UMS4 (Residues: 1-504; Coverage: 100%)
Gene names: NMP200, PRP19, PRPF19, SNEV
Pfam:
InterPro:
Pre-mRNA-processing factor 19 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-processing factor 19 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-processing factor 19 in PDB entry 7w5a, assembly 1, top view.
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U2 small nuclear ribonucleoprotein A'
Chain: o
Length: 255 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09661 (Residues: 1-255; Coverage: 100%)
Gene name: SNRPA1
Pfam: Leucine-rich repeat
InterPro:
U2 small nuclear ribonucleoprotein A' in PDB entry 7w5a, assembly 1, front view.
U2 small nuclear ribonucleoprotein A' in PDB entry 7w5a, assembly 1, side view.
U2 small nuclear ribonucleoprotein A' in PDB entry 7w5a, assembly 1, top view.
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U2 small nuclear ribonucleoprotein B''
Chain: p
Length: 225 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08579 (Residues: 1-225; Coverage: 100%)
Gene name: SNRPB2
Pfam: RNA recognition motif
InterPro:
U2 small nuclear ribonucleoprotein B'' in PDB entry 7w5a, assembly 1, front view.
U2 small nuclear ribonucleoprotein B'' in PDB entry 7w5a, assembly 1, side view.
U2 small nuclear ribonucleoprotein B'' in PDB entry 7w5a, assembly 1, top view.
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Pre-mRNA-splicing factor SLU7
Chain: 1
Length: 586 amino acids
Theoretical weight: 68.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95391 (Residues: 1-586; Coverage: 100%)
Gene name: SLU7
Pfam: Pre-mRNA splicing Prp18-interacting factor
InterPro:
Pre-mRNA-splicing factor SLU7 in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA-splicing factor SLU7 in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA-splicing factor SLU7 in PDB entry 7w5a, assembly 1, top view.
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RNA chain B
Name: U5 snRNA
Representative chains: B
Length: 117 nucleotides
Theoretical weight: 37.25 KDa
Rfam: U5 spliceosomal RNA
U5 snRNA in PDB entry 7w5a, assembly 1, front view.
U5 snRNA in PDB entry 7w5a, assembly 1, side view.
U5 snRNA in PDB entry 7w5a, assembly 1, top view.
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RNA chain F
Name: U6 snRNA
Representative chains: F
Length: 107 nucleotides
Theoretical weight: 34.4 KDa
Rfam: U6 spliceosomal RNA
U6 snRNA in PDB entry 7w5a, assembly 1, front view.
U6 snRNA in PDB entry 7w5a, assembly 1, side view.
U6 snRNA in PDB entry 7w5a, assembly 1, top view.
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RNA chain 4
Name: Pre-mRNA
Representative chains: 4
Length: 46 nucleotides
Theoretical weight: 14.73 KDa
Pre-mRNA in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA in PDB entry 7w5a, assembly 1, top view.
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RNA chain G
Name: Pre-mRNA
Representative chains: G
Length: 174 nucleotides
Theoretical weight: 55.66 KDa
Pre-mRNA in PDB entry 7w5a, assembly 1, front view.
Pre-mRNA in PDB entry 7w5a, assembly 1, side view.
Pre-mRNA in PDB entry 7w5a, assembly 1, top view.
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RNA chain H
Name: U2 snRNA
Representative chains: H
Length: 188 nucleotides
Theoretical weight: 60.19 KDa
Rfam: U2 spliceosomal RNA
U2 snRNA in PDB entry 7w5a, assembly 1, front view.
U2 snRNA in PDB entry 7w5a, assembly 1, side view.
U2 snRNA in PDB entry 7w5a, assembly 1, top view.
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