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The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide

X-ray diffraction
2.68Å resolution
PDB entry 7w6j coloured by chain, front view.
PDB entry 7w6j coloured by chain, side view.
PDB entry 7w6j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 18543.87 Å2
Buried surface area: 3671.47 Å2
Dissociation area: 1,021.4 Å2
Dissociation energy (ΔGdiss): -9.37 kcal/mol
Dissociation entropy (TΔSdiss): 21.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169857

Macromolecules

Set1/Ash2 histone methyltransferase complex subunit ASH2
Chain: A
Length: 184 amino acids
Theoretical weight: 20.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBL3 (Residues: 380-496, 516-598; Coverage: 28%)
Gene names: ASH2L, ASH2L1
Pfam: SPRY domain
InterPro:
Set1/Ash2 histone methyltransferase complex subunit ASH2 in PDB entry 7w6j, assembly 1, front view.
Set1/Ash2 histone methyltransferase complex subunit ASH2 in PDB entry 7w6j, assembly 1, side view.
Set1/Ash2 histone methyltransferase complex subunit ASH2 in PDB entry 7w6j, assembly 1, top view.
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MLL cleavage product C180
Chain: C
Length: 159 amino acids
Theoretical weight: 18.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03164 (Residues: 3813-3881, 3882-3969; Coverage: 4%)
Gene names: ALL1, CXXC7, HRX, HTRX, KMT2A, MLL, MLL1, TRX1
Pfam: SET domain
InterPro:
MLL cleavage product C180 in PDB entry 7w6j, assembly 1, front view.
MLL cleavage product C180 in PDB entry 7w6j, assembly 1, side view.
MLL cleavage product C180 in PDB entry 7w6j, assembly 1, top view.
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Retinoblastoma-binding protein 5
Chain: F
Length: 27 amino acids
Theoretical weight: 3.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15291 (Residues: 330-356; Coverage: 5%)
Gene names: RBBP5, RBQ3
Retinoblastoma-binding protein 5 in PDB entry 7w6j, assembly 1, front view.
Retinoblastoma-binding protein 5 in PDB entry 7w6j, assembly 1, side view.
Retinoblastoma-binding protein 5 in PDB entry 7w6j, assembly 1, top view.
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Histone H3.3C
Chain: B
Length: 9 amino acids
Theoretical weight: 1.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6NXT2 (Residues: 2-10; Coverage: 7%)
Gene names: H3-5, H3F3C
Histone H3.3C in PDB entry 7w6j, assembly 1, front view.
Histone H3.3C in PDB entry 7w6j, assembly 1, side view.
Histone H3.3C in PDB entry 7w6j, assembly 1, top view.
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