› 7wc4

X-ray diffraction
3.2Å resolution

Crystal structure of serotonin 2A receptor in complex with serotonin

Released:
DOI: 10.2210/pdb7wc4/pdb
PDB entry 7wc4 coloured by chain, front view.
PDB entry 7wc4 coloured by chain, side view.
PDB entry 7wc4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based discovery of nonhallucinogenic psychedelic analogs.
Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S
Science 375 403-411 (2022)
PMID: 35084960

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 2A Chain: A
Molecule details ›
Chain: A
Length: 376 amino acids
Theoretical weight: 42.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P28223 (Residues: 67-265, 266-268, 269-288, 289-292, 293-308, 309-403; Coverage: 72%)
Gene names: HTR2, HTR2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

5 bound ligands:
Ligand CLR 3 x CLR
Ligand 1PE 1 x 1PE
Ligand OLC 3 x OLC
Ligand MG 1 x MG
Ligand SRO 1 x SRO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45XU
Unit cell:
a: 49.9Å b: 54.73Å c: 178.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.261
Expression system: Spodoptera frugiperda

Quick links

Citations

31 review citations

The neural basis of psychedelic action.
Kwan et al. (2022)
30 more

9 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
8 more