› 7wd3

Electron Microscopy
3.8Å resolution

Cryo-EM structure of Drg1 hexamer treated with ATP and benzo-diazaborine

Released:
DOI: 10.2210/pdb7wd3/pdb
PDB entry 7wd3 coloured by chain, front view.
PDB entry 7wd3 coloured by chain, side view.
PDB entry 7wd3 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Ma C, Wu D, Chen Q, Gao N
OpenAccess logo Nat Commun 13 6765 (2022)
PMID: 36351914
Related structures: EMD-32403

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152459 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family gene 2 protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 748 amino acids
Theoretical weight: 81.78 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P32794 (Residues: 29-776; Coverage: 96%)
Gene names: AFG2, DRG1, L8084.16, YLR397C
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 12 x ATP
Ligand NDT 12 x NDT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-32403
Expression system: Escherichia coli

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Citations

3 citation in other articles

Nuclear export of pre-60S particles through the nuclear pore complex.
Li et al. (2023)
2 more