› 7wk6

Electron Microscopy
3.67Å resolution

Cryo-EM structure of SARS-CoV-2 Omicron spike protein with human ACE2 (focus refinement on RBD-1/ACE2)

Released:
DOI: 10.2210/pdb7wk6/pdb
PDB entry 7wk6 coloured by chain, front view.
PDB entry 7wk6 coloured by chain, side view.
PDB entry 7wk6 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of receptor binding and antibody neutralization of Omicron
Hong Q, Han W, Li J, Xu S, Wang Y, Xu C, Li Z, Wang Y, Zhang C, Huang Z, Cong Y
Nature 604 546-552 (2022)
Related structures: EMD-32560

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike glycoprotein Chain: E
Molecule details ›
Chain: E
Length: 1258 amino acids
Theoretical weight: 140.21 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-210, 211-211, 215-1208; Coverage: 94%)
Gene names: 2, S
Sequence domains:
Processed angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 625 amino acids
Theoretical weight: 72.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 17-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.67Å
Relevant EMDB volumes: EMD-32560
Expression system: Homo sapiens

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