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CryoEM structure of human alpha-synuclein A53T fibril

Electron Microscopy
3.4Å resolution
PDB entry 7wnz coloured by chain, front view.
PDB entry 7wnz coloured by chain, side view.
PDB entry 7wnz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo decamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-synuclein
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Multimeric state: homo decamer
Accessible surface area: 23901.69 Å2
Buried surface area: 42315.69 Å2
Dissociation area: 1,295.67 Å2
Dissociation energy (ΔGdiss): 8.36 kcal/mol
Dissociation entropy (TΔSdiss): 13.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153502

Macromolecules

Alpha-synuclein
Chains: A, B, C, D, E, F, G, H, I, J
Length: 65 amino acids
Theoretical weight: 6.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37840 (Residues: 36-100; Coverage: 46%)
Gene names: NACP, PARK1, SNCA
Pfam: Synuclein
InterPro:
Alpha-synuclein in PDB entry 7wnz, assembly 1, front view.
Alpha-synuclein in PDB entry 7wnz, assembly 1, side view.
Alpha-synuclein in PDB entry 7wnz, assembly 1, top view.
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