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Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK1628x in complex with three neutralizing antibodies

Electron Microscopy
3.88Å resolution
PDB entry 7wp8 coloured by chain, front view.
PDB entry 7wp8 coloured by chain, side view.
PDB entry 7wp8 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero heptamer (preferred)
Entry contents: 7 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spike protein S2' and IG-light kappa chain and IG-heavy chain and IG-heavy chain and IG-light kappa chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero heptamer
Accessible surface area: 36875.5 Å2
Buried surface area: 11697.9 Å2
Dissociation area: 923.41 Å2
Dissociation energy (ΔGdiss): -8.64 kcal/mol
Dissociation entropy (TΔSdiss): 13.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225225

Macromolecules

83H7 light chain
Chain: C
Length: 104 amino acids
Theoretical weight: 11.43 KDa
Source organism: Mus musculus
InterPro:
83H7 light chain in PDB entry 7wp8, assembly 1, front view.
83H7 light chain in PDB entry 7wp8, assembly 1, side view.
83H7 light chain in PDB entry 7wp8, assembly 1, top view.
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83H7 heavy chain
Chain: D
Length: 118 amino acids
Theoretical weight: 13.03 KDa
Source organism: Mus musculus
InterPro:
83H7 heavy chain in PDB entry 7wp8, assembly 1, front view.
83H7 heavy chain in PDB entry 7wp8, assembly 1, side view.
83H7 heavy chain in PDB entry 7wp8, assembly 1, top view.
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2B4 heavy chain
Chain: E
Length: 119 amino acids
Theoretical weight: 13.68 KDa
Source organism: Mus musculus
InterPro:
2B4 heavy chain in PDB entry 7wp8, assembly 1, front view.
2B4 heavy chain in PDB entry 7wp8, assembly 1, side view.
2B4 heavy chain in PDB entry 7wp8, assembly 1, top view.
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Spike protein S1
Chain: F
Length: 183 amino acids
Theoretical weight: 20.8 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DTC2 (Residues: 336-518; Coverage: 15%)
Gene names: 2, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding
InterPro:
Spike protein S1 in PDB entry 7wp8, assembly 1, front view.
Spike protein S1 in PDB entry 7wp8, assembly 1, side view.
Spike protein S1 in PDB entry 7wp8, assembly 1, top view.
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2B4 light chain
Chain: G
Length: 113 amino acids
Theoretical weight: 12.45 KDa
Source organism: Mus musculus
InterPro:
2B4 light chain in PDB entry 7wp8, assembly 1, front view.
2B4 light chain in PDB entry 7wp8, assembly 1, side view.
2B4 light chain in PDB entry 7wp8, assembly 1, top view.
Molecule details ›

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85F7 heavy chain
Chain: H
Length: 118 amino acids
Theoretical weight: 13.16 KDa
Source organism: Mus musculus
InterPro:
85F7 heavy chain in PDB entry 7wp8, assembly 1, front view.
85F7 heavy chain in PDB entry 7wp8, assembly 1, side view.
85F7 heavy chain in PDB entry 7wp8, assembly 1, top view.
Molecule details ›

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85F7 light chain
Chain: L
Length: 106 amino acids
Theoretical weight: 11.28 KDa
Source organism: Mus musculus
InterPro:
85F7 light chain in PDB entry 7wp8, assembly 1, front view.
85F7 light chain in PDB entry 7wp8, assembly 1, side view.
85F7 light chain in PDB entry 7wp8, assembly 1, top view.
Molecule details ›

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