› 7wqo

Electron Microscopy
2.85Å resolution

Structure of Adeno-associated virus serotype PHP.eB

Released:
DOI: 10.2210/pdb7wqo/pdb
PDB entry 7wqo coloured by chain, front view.
PDB entry 7wqo coloured by chain, side view.
PDB entry 7wqo coloured by chain, top view.
Source organism: Adeno-associated virus 9
Primary publication:
Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors.
Xu G, Zhang R, Li H, Yin K, Ma X, Lou Z
Mol Ther Methods Clin Dev 26 52-60 (2022)
PMID: 35755945
Related structures: EMD-32711

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 525 amino acids
Theoretical weight: 59.21 KDa
Source organism: Adeno-associated virus 9
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6JC40 (Residues: 219-586, 587-736; Coverage: 70%)
Gene name: cap
Sequence domains: Parvovirus coat protein VP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.85Å
Relevant EMDB volumes: EMD-32711
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Advances in Recombinant Adeno-Associated Virus Vectors for Neurodegenerative Diseases.
Li et al. (2023)
3 more

2 mentions without citation

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors.
Xu et al. (2022)
1 more