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Structure of Adeno-associated virus serotype PHP.eB

Electron Microscopy
2.85Å resolution
PDB entry 7wqo coloured by chain, front view.
PDB entry 7wqo coloured by chain, side view.
PDB entry 7wqo coloured by chain, top view.
Source organism: Adeno-associated virus 9
Assembly composition:
homo 60-mer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Capsid protein VP1
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Multimeric state: homo 60-mer
Accessible surface area: 862425.72 Å2
Buried surface area: 943484.01 Å2
Dissociation area: 191,163.83 Å2
Dissociation energy (ΔGdiss): 2,758.9 kcal/mol
Dissociation entropy (TΔSdiss): 371.74 kcal/mol
Symmetry number: 60
PDBe Complex ID: PDB-CPX-179812

Macromolecules

Capsid protein VP1
Chain: A
Length: 525 amino acids
Theoretical weight: 59.21 KDa
Source organism: Adeno-associated virus 9
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6JC40 (Residues: 219-586, 587-736; Coverage: 70%)
Gene name: cap
Pfam: Parvovirus coat protein VP2
InterPro:
Capsid protein VP1 in PDB entry 7wqo, assembly 1, front view.
Capsid protein VP1 in PDB entry 7wqo, assembly 1, side view.
Capsid protein VP1 in PDB entry 7wqo, assembly 1, top view.
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