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Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development

Electron Microscopy
3.4Å resolution
PDB entry 7ws7 coloured by chain, front view.
PDB entry 7ws7 coloured by chain, side view.
PDB entry 7ws7 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spike protein S2' and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero pentamer
Accessible surface area: 30409.87 Å2
Buried surface area: 6603.88 Å2
Dissociation area: 3,130.72 Å2
Dissociation energy (ΔGdiss): -7.3 kcal/mol
Dissociation entropy (TΔSdiss): 47.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209996

Macromolecules

Spike protein S1
Chain: B
Length: 205 amino acids
Theoretical weight: 23.06 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 326-530; Coverage: 16%)
Gene names: 2, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding
InterPro:
Spike protein S1 in PDB entry 7ws7, assembly 1, front view.
Spike protein S1 in PDB entry 7ws7, assembly 1, side view.
Spike protein S1 in PDB entry 7ws7, assembly 1, top view.
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510A5 light chain
Chains: F, J
Length: 108 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
510A5 light chain in PDB entry 7ws7, assembly 1, front view.
510A5 light chain in PDB entry 7ws7, assembly 1, side view.
510A5 light chain in PDB entry 7ws7, assembly 1, top view.
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510A5 heavy chain
Chains: G, K
Length: 125 amino acids
Theoretical weight: 13.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
510A5 heavy chain in PDB entry 7ws7, assembly 1, front view.
510A5 heavy chain in PDB entry 7ws7, assembly 1, side view.
510A5 heavy chain in PDB entry 7ws7, assembly 1, top view.
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