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Cryo-EM structure of SARS-CoV spike receptor-binding domain in complex with sea lion ACE2

Source organisms:
Biochemical function: peptidyl-dipeptidase activity
Biological process: proteolysis
Cellular component: membrane

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EC 3.4.17.23: Angiotensin-converting enzyme 2

Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Systematic name:
-
Alternative Name(s):
  • ACE-2
  • ACE2
  • Angiotensin converting enzyme 2
  • Angiotensin converting enzyme-2
  • HACE2
  • Tmem27

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF09408
Domain description: Betacoronavirus spike glycoprotein S1, receptor binding
Occurring in:
  1. Spike protein S1
The deposited structure of PDB entry 7wsg contains 1 copy of Pfam domain PF09408 ( Betacoronavirus spike glycoprotein S1, receptor binding) in Spike protein S1. Showing 1 copy in chain B.

PF16959
Domain description: Renal amino acid transporter
Occurring in:
  1. Angiotensin-converting enzyme
The deposited structure of PDB entry 7wsg contains 1 copy of Pfam domain PF16959 (Renal amino acid transporter) in Angiotensin-converting enzyme. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF01401
Domain description: Angiotensin-converting enzyme
Occurring in:
  1. Angiotensin-converting enzyme
The deposited structure of PDB entry 7wsg contains 1 copy of Pfam domain PF01401 (Angiotensin-converting enzyme) in Angiotensin-converting enzyme. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001548
Domain description: Peptidase M2, peptidyl-dipeptidase A
Occurring in:
  1. Angiotensin-converting enzyme
IPR018548
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
Occurring in:
  1. Spike protein S1
IPR036326
Domain description: Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
Occurring in:
  1. Spike protein S1
IPR031588
Domain description: Collectrin domain
Occurring in:
  1. Angiotensin-converting enzyme

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