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Cryo-EM structure of SARS-CoV-2 spike receptor-binding domain in complex with sea lion ACE2

Electron Microscopy
2.89Å resolution
PDB entry 7wsh coloured by chain, front view.
PDB entry 7wsh coloured by chain, side view.
PDB entry 7wsh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spike protein S2' and Angiotensin-converting enzyme
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Multimeric state: hetero dimer
Accessible surface area: 33939.85 Å2
Buried surface area: 2167.63 Å2
Dissociation area: 888.73 Å2
Dissociation energy (ΔGdiss): -2.38 kcal/mol
Dissociation entropy (TΔSdiss): 13.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-105659

Macromolecules

Angiotensin-converting enzyme
Chain: A
Length: 806 amino acids
Theoretical weight: 93.01 KDa
Source organism: Mammalia
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A6J2EID0 (Residues: 1-806; Coverage: 100%)
Gene name: ACE2
Pfam:
InterPro:
Angiotensin-converting enzyme in PDB entry 7wsh, assembly 1, front view.
Angiotensin-converting enzyme in PDB entry 7wsh, assembly 1, side view.
Angiotensin-converting enzyme in PDB entry 7wsh, assembly 1, top view.
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Spike protein S1
Chain: B
Length: 195 amino acids
Theoretical weight: 21.87 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 333-527; Coverage: 16%)
Gene names: 2, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding
InterPro:
Spike protein S1 in PDB entry 7wsh, assembly 1, front view.
Spike protein S1 in PDB entry 7wsh, assembly 1, side view.
Spike protein S1 in PDB entry 7wsh, assembly 1, top view.
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