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Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi protein

Electron Microscopy
3.36Å resolution
PDB entry 7wv9 coloured by chain, front view.
PDB entry 7wv9 coloured by chain, side view.
PDB entry 7wv9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 52571.39 Å2
Buried surface area: 10476.03 Å2
Dissociation area: 901.69 Å2
Dissociation energy (ΔGdiss): -3.6 kcal/mol
Dissociation entropy (TΔSdiss): 13.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225038

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-2
Chain: A
Length: 355 amino acids
Theoretical weight: 40.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(i) subunit alpha-2 in PDB entry 7wv9, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-2 in PDB entry 7wv9, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-2 in PDB entry 7wv9, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 359 amino acids
Theoretical weight: 39.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7wv9, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7wv9, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 7wv9, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7wv9, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7wv9, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 7wv9, assembly 1, top view.
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Cannabinoid receptor 1
Chain: R
Length: 472 amino acids
Theoretical weight: 52.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Cannabinoid receptor 1 in PDB entry 7wv9, assembly 1, front view.
Cannabinoid receptor 1 in PDB entry 7wv9, assembly 1, side view.
Cannabinoid receptor 1 in PDB entry 7wv9, assembly 1, top view.
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ScFv16
Chain: S
Length: 266 amino acids
Theoretical weight: 28.64 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
ScFv16 in PDB entry 7wv9, assembly 1, front view.
ScFv16 in PDB entry 7wv9, assembly 1, side view.
ScFv16 in PDB entry 7wv9, assembly 1, top view.
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