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CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with the nascent chitooligosaccharide

Source organism: Phytophthora sojae strain P6497
Biochemical function: hexosyltransferase activity
Biological process: cell wall organization
Cellular component: cell periphery

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EC 2.4.1.16: Chitin synthase

Reaction catalysed:
UDP-N-acetyl-alpha-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1)
Systematic name:
UDP-N-acetyl-alpha-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase (configuration-retaining)
Alternative Name(s):
  • Chitin synthetase
  • Chitin-UDP N-acetylglucosaminyltransferase
  • Chitin-UDP acetyl-glucosaminyl transferase
  • Chitin-uridine diphosphate acetylglucosaminyltransferase
  • Trans-N-acetylglucosaminosylase
  • UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01644
Domain description: Chitin synthase
Occurring in:
  1. Chitin synthase 1
The deposited structure of PDB entry 7x05 contains 2 copies of Pfam domain PF01644 (Chitin synthase) in chitin synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Chitin synthase 1
IPR004834
Domain description: Fungal chitin synthase
Occurring in:
  1. Chitin synthase 1
IPR004835
Domain description: Chitin synthase
Occurring in:
  1. Chitin synthase 1

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