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Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 8A10 (CVB1-pre-A:8A10)

Source organisms:
Biochemical function: structural molecule activity
Biological process: not assigned
Cellular component: viral capsid

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EC 3.4.22.29: Picornain 2A

Reaction catalysed:
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
Systematic name:
-
Alternative Name(s):
  • 2A protease
  • 2A proteinase
  • Picornaviral 2A proteinase
  • Picornavirus endopeptidase 2A
  • Poliovirus protease 2A
  • Poliovirus protease 2A-Pro
  • Poliovirus proteinase 2A
  • Protease 2A
  • Proteinase 2A-Pro
  • Rhinovirus protease 2A
  • Y-G proteinase 2A

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.22.28: Picornain 3C

Reaction catalysed:
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Alternative Name(s):
  • 3C protease
  • 3C proteinase
  • Coxsackievirus 3C proteinase
  • Cysteine proteinase 3C
  • Foot-and-mouth protease 3C
  • Foot-and-mouth-disease virus proteinase 3C
  • Hepatitis A virus 3C proteinase
  • Picornavirus endopeptidase 3C
  • Poliovirus protease 3C
  • Poliovirus proteinase 3C
  • Protease 3C
  • Rhinovirus protease 3C
  • Rhinovirus proteinase 3C
  • Tomato ringspot nepovirus 3C-related protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00073
Domain description: picornavirus capsid protein
Occurring in:
  1. Virion protein 1
  2. VP2
  3. VP3
The deposited structure of PDB entry 7x2w contains 1 copy of Pfam domain PF00073 (picornavirus capsid protein) in Virion protein 1. Showing 1 copy in chain C [auth A].
The deposited structure of PDB entry 7x2w contains 1 copy of Pfam domain PF00073 (picornavirus capsid protein) in VP2. Showing 1 copy in chain D [auth B].
The deposited structure of PDB entry 7x2w contains 1 copy of Pfam domain PF00073 (picornavirus capsid protein) in VP3. Showing 1 copy in chain E [auth C].

PF02226
Domain description: Picornavirus coat protein (VP4)
Occurring in:
  1. Capsid protein VP4
The deposited structure of PDB entry 7x2w contains 1 copy of Pfam domain PF02226 (Picornavirus coat protein (VP4)) in Capsid protein VP4. Showing 1 copy in chain F [auth D].

InterPro InterPro annotations
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. 8A10 heavy chain
  2. 8A10 light chain
IPR033703
Domain description: Picornavirus/Calicivirus coat protein
Occurring in:
  1. Virion protein 1
  2. VP2
  3. VP3
IPR001676
Domain description: Picornavirus capsid
Occurring in:
  1. Virion protein 1
  2. VP2
  3. VP3
IPR029053
Domain description: Viral coat protein subunit
Occurring in:
  1. Virion protein 1
  2. VP2
  3. VP3
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. 8A10 heavy chain
  2. 8A10 light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. 8A10 heavy chain
  2. 8A10 light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. 8A10 heavy chain
  2. 8A10 light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. 8A10 heavy chain
  2. 8A10 light chain
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. 8A10 heavy chain
IPR003138
Domain description: Picornavirus coat protein VP4
Occurring in:
  1. Capsid protein VP4
IPR036988
Domain description: Picornavirus coat protein VP4 superfamily
Occurring in:
  1. Capsid protein VP4

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