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Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 8A10 (CVB1-pre-A:8A10)

Electron Microscopy
3.24Å resolution
PDB entry 7x2w coloured by chain, front view.
PDB entry 7x2w coloured by chain, side view.
PDB entry 7x2w coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 360-mer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Virion protein 1 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero 360-mer
Accessible surface area: 1578024.74 Å2
Buried surface area: 2436531.71 Å2
Dissociation area: 144,269.13 Å2
Dissociation energy (ΔGdiss): 33.95 kcal/mol
Dissociation entropy (TΔSdiss): 1,514.45 kcal/mol
Symmetry number: 60
PDBe Complex ID: PDB-CPX-224687

Macromolecules

8A10 light chain
Chain: L
Length: 108 amino acids
Theoretical weight: 11.95 KDa
Source organism: Mus musculus
8A10 light chain in PDB entry 7x2w, assembly 1, front view.
8A10 light chain in PDB entry 7x2w, assembly 1, side view.
8A10 light chain in PDB entry 7x2w, assembly 1, top view.
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8A10 heavy chain
Chain: H
Length: 118 amino acids
Theoretical weight: 13.32 KDa
Source organism: Mus musculus
8A10 heavy chain in PDB entry 7x2w, assembly 1, front view.
8A10 heavy chain in PDB entry 7x2w, assembly 1, side view.
8A10 heavy chain in PDB entry 7x2w, assembly 1, top view.
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Virion protein 1
Chain: A
Length: 278 amino acids
Theoretical weight: 31.21 KDa
Source organism: Coxsackievirus B1
Virion protein 1 in PDB entry 7x2w, assembly 1, front view.
Virion protein 1 in PDB entry 7x2w, assembly 1, side view.
Virion protein 1 in PDB entry 7x2w, assembly 1, top view.
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VP2
Chain: B
Length: 263 amino acids
Theoretical weight: 29.12 KDa
Source organism: Coxsackievirus B1
VP2 in PDB entry 7x2w, assembly 1, front view.
VP2 in PDB entry 7x2w, assembly 1, side view.
VP2 in PDB entry 7x2w, assembly 1, top view.
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VP3
Chain: C
Length: 238 amino acids
Theoretical weight: 26.33 KDa
Source organism: Coxsackievirus B1
VP3 in PDB entry 7x2w, assembly 1, front view.
VP3 in PDB entry 7x2w, assembly 1, side view.
VP3 in PDB entry 7x2w, assembly 1, top view.
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Capsid protein VP4
Chain: D
Length: 69 amino acids
Theoretical weight: 7.48 KDa
Source organism: Coxsackievirus B1
Capsid protein VP4 in PDB entry 7x2w, assembly 1, front view.
Capsid protein VP4 in PDB entry 7x2w, assembly 1, side view.
Capsid protein VP4 in PDB entry 7x2w, assembly 1, top view.
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