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Cryo-EM structure of Coxsackievirus B1 pre-A-particle in complex with nAb 9A3 (CVB1-pre-A:9A3)

Electron Microscopy
3.44Å resolution
PDB entry 7x3e coloured by chain, front view.
PDB entry 7x3e coloured by chain, side view.
PDB entry 7x3e coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 360-mer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Virion protein 1 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero 360-mer
Accessible surface area: 1660127.58 Å2
Buried surface area: 2334569.46 Å2
Dissociation area: 56,764.87 Å2
Dissociation energy (ΔGdiss): -447.81 kcal/mol
Dissociation entropy (TΔSdiss): 846.75 kcal/mol
Symmetry number: 60
PDBe Complex ID: PDB-CPX-224690

Macromolecules

Virion protein 1
Chain: A
Length: 278 amino acids
Theoretical weight: 31.21 KDa
Source organism: Coxsackievirus B1
UniProt:
  • Canonical: A0A7T7KAA0 (Residues: 571-848; Coverage: 33%)
Pfam: picornavirus capsid protein
InterPro:
Virion protein 1 in PDB entry 7x3e, assembly 1, front view.
Virion protein 1 in PDB entry 7x3e, assembly 1, side view.
Virion protein 1 in PDB entry 7x3e, assembly 1, top view.
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VP2
Chain: B
Length: 263 amino acids
Theoretical weight: 29.12 KDa
Source organism: Coxsackievirus B1
UniProt:
  • Canonical: A0A7T7KAA0 (Residues: 70-332; Coverage: 31%)
Pfam: picornavirus capsid protein
InterPro:
VP2 in PDB entry 7x3e, assembly 1, front view.
VP2 in PDB entry 7x3e, assembly 1, side view.
VP2 in PDB entry 7x3e, assembly 1, top view.
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VP3
Chain: C
Length: 238 amino acids
Theoretical weight: 26.33 KDa
Source organism: Coxsackievirus B1
UniProt:
  • Canonical: A0A7T7KAA0 (Residues: 333-570; Coverage: 28%)
Pfam: picornavirus capsid protein
InterPro:
VP3 in PDB entry 7x3e, assembly 1, front view.
VP3 in PDB entry 7x3e, assembly 1, side view.
VP3 in PDB entry 7x3e, assembly 1, top view.
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Capsid protein VP4
Chain: D
Length: 69 amino acids
Theoretical weight: 7.48 KDa
Source organism: Coxsackievirus B1
UniProt: Pfam: Picornavirus coat protein (VP4)
InterPro:
Capsid protein VP4 in PDB entry 7x3e, assembly 1, front view.
Capsid protein VP4 in PDB entry 7x3e, assembly 1, side view.
Capsid protein VP4 in PDB entry 7x3e, assembly 1, top view.
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9A3 heavy chain
Chain: H
Length: 124 amino acids
Theoretical weight: 13.77 KDa
Source organism: Mus musculus
InterPro:
9A3 heavy chain in PDB entry 7x3e, assembly 1, front view.
9A3 heavy chain in PDB entry 7x3e, assembly 1, side view.
9A3 heavy chain in PDB entry 7x3e, assembly 1, top view.
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9A3 light chain
Chain: L
Length: 108 amino acids
Theoretical weight: 11.47 KDa
Source organism: Mus musculus
InterPro:
9A3 light chain in PDB entry 7x3e, assembly 1, front view.
9A3 light chain in PDB entry 7x3e, assembly 1, side view.
9A3 light chain in PDB entry 7x3e, assembly 1, top view.
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