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Structure of mTRPV2_Q525F

Electron Microscopy
2.59Å resolution
PDB entry 7xew coloured by chain, front view.
PDB entry 7xew coloured by chain, side view.
PDB entry 7xew coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transient receptor potential cation channel subfamily V member 2
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Multimeric state: homo tetramer
Accessible surface area: 110043.11 Å2
Buried surface area: 20883.07 Å2
Dissociation area: 10,441.54 Å2
Dissociation energy (ΔGdiss): 170.53 kcal/mol
Dissociation entropy (TΔSdiss): 50.24 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-194380

Macromolecules

Transient receptor potential cation channel subfamily V member 2
Chains: A, B, C, D
Length: 756 amino acids
Theoretical weight: 86.08 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9WTR1 (Residues: 1-756; Coverage: 100%)
Gene names: Grc, Trpv2
Pfam:
InterPro:
Transient receptor potential cation channel subfamily V member 2 in PDB entry 7xew, assembly 1, front view.
Transient receptor potential cation channel subfamily V member 2 in PDB entry 7xew, assembly 1, side view.
Transient receptor potential cation channel subfamily V member 2 in PDB entry 7xew, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9WTR1  
1756100200300400500600700
 
200400600MTSASNPPAFRLETSDGDEEGSAEVNKGKNEPPPMESPFQGEDRNFSPQIKVNLNYRKGLGPSQQDPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQREFSGLYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPHRHRMVVLEPLNKLLQEKWDRLIPRFFFNFACYLVYMIIFTIVAYHQPSLEQPAIPSSKATFGDSMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFVETEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIFKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDSNTTVTEKPTLGQEEEPVPYGGILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKRHRAGRLLKVGTKGDGIPDERWCFRVEEVNWAAWEKTLPTLSEDPSGAGITGYKKNPTSKPGKNSASEEDHLPLQVLQSH
UniProt
Q9WTR1
Chains
Domains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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