› 7xlq

Electron Microscopy
3.1Å resolution

Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state

Released:
DOI: 10.2210/pdb7xlq/pdb
PDB entry 7xlq coloured by chain, front view.
PDB entry 7xlq coloured by chain, side view.
PDB entry 7xlq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3.
Gao Y, Xu S, Cui X, Xu H, Qiu Y, Wei Y, Dong Y, Zhu B, Peng C, Liu S, Zhang XC, Sun J, Huang Z, Zhao Y
OpenAccess logo Nat Commun 14 516 (2023)
PMID: 36720859
Related structures: EMD-33285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156988 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Voltage-dependent R-type calcium channel subunit alpha-1E Chain: A
Molecule details ›
Chain: A
Length: 2313 amino acids
Theoretical weight: 262.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15878 (Residues: 1-2313; Coverage: 100%)
Gene names: CACH6, CACNA1E, CACNL1A6
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1077 amino acids
Theoretical weight: 122.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 27-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 598 amino acids
Theoretical weight: 65.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02641 (Residues: 1-598; Coverage: 100%)
Gene names: CACNB1, CACNLB1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
5 bound ligands:
Ligand Y01 6 x Y01
Ligand R16 7 x R16
Ligand 3PE 1 x 3PE
Ligand CA 2 x CA
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-33285
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.
Perez-Miller et al. (2024)
1 more

1 mention without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)