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E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A filament bound with ADP, Pi and R5P

Electron Microscopy
2.3Å resolution
PDB entry 7xmu coloured by chain, front view.
PDB entry 7xmu coloured by chain, side view.
PDB entry 7xmu coloured by chain, top view.
Source organism: Escherichia coli str. K-12 substr. MG1655
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribose-phosphate pyrophosphokinase
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Multimeric state: homo hexamer
Accessible surface area: 57822.03 Å2
Buried surface area: 38363.94 Å2
Dissociation area: 8,604.79 Å2
Dissociation energy (ΔGdiss): 63.74 kcal/mol
Dissociation entropy (TΔSdiss): 31.66 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-141507

Macromolecules

Ribose-phosphate pyrophosphokinase
Chains: A, B, C, D, E, F
Length: 321 amino acids
Theoretical weight: 35.08 KDa
Source organism: Escherichia coli str. K-12 substr. MG1655
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P0A717 (Residues: 1-315; Coverage: 100%)
Gene names: JW1198, b1207, prs, prsA
Pfam:
InterPro:
Ribose-phosphate pyrophosphokinase in PDB entry 7xmu, assembly 1, front view.
Ribose-phosphate pyrophosphokinase in PDB entry 7xmu, assembly 1, side view.
Ribose-phosphate pyrophosphokinase in PDB entry 7xmu, assembly 1, top view.
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