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MEK1 bound to DS94070624

X-ray diffraction
2.1Å resolution
PDB entry 7xnc coloured by chain, front view.
PDB entry 7xnc coloured by chain, side view.
PDB entry 7xnc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dual specificity mitogen-activated protein kinase kinase 1
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Multimeric state: monomeric
Accessible surface area: 14362.41 Å2
Buried surface area: 463.14 Å2
Dissociation area: 93.71 Å2
Dissociation energy (ΔGdiss): -2.62 kcal/mol
Dissociation entropy (TΔSdiss): 0.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169744

Macromolecules

Dual specificity mitogen-activated protein kinase kinase 1
Chain: A
Length: 348 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02750 (Residues: 37-383; Coverage: 88%)
Gene names: MAP2K1, MEK1, PRKMK1
Pfam: Protein kinase domain
InterPro:
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7xnc, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7xnc, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7xnc, assembly 1, top view.
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