› 7xoh

Electron Microscopy
3.6Å resolution

Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine.

Released:
DOI: 10.2210/pdb7xoh/pdb
PDB entry 7xoh coloured by chain, front view.
PDB entry 7xoh coloured by chain, side view.
PDB entry 7xoh coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
S-Adenosylmethionine-responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
Bandyopadhyay P, Pramanick I, Biswas R, Ps S, Sreedharan S, Singh S, Rajmani RS, Laxman S, Dutta S, Singh A
OpenAccess logo Sci Adv 8 eabo0097 (2022)
PMID: 35749503
Related structures: EMD-33348

Function and Biology Details

Reaction catalysed: 
L-serine + L-homocysteine = L-cystathionine + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-552351 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable cystathionine beta-synthase Rv1077 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 478 amino acids
Theoretical weight: 50.28 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WP51 (Residues: 2-464; Coverage: 100%)
Gene names: Rv1077, cbs
Sequence domains:

Ligands and Environments


Cofactor: Ligand PLP 4 x PLP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-33348
Expression system: Escherichia coli

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Citations

1 review citation

Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease.
Liu et al. (2022)
4 other articles