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Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine.

Electron Microscopy
3.6Å resolution
PDB entry 7xoh coloured by chain, front view.
PDB entry 7xoh coloured by chain, side view.
PDB entry 7xoh coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Probable cystathionine beta-synthase Rv1077
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Multimeric state: homo tetramer
Accessible surface area: 71202.11 Å2
Buried surface area: 17290.4 Å2
Dissociation area: 3,885.36 Å2
Dissociation energy (ΔGdiss): 33.19 kcal/mol
Dissociation entropy (TΔSdiss): 16.74 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-552351

Macromolecules

Probable cystathionine beta-synthase Rv1077
Chains: A, B, C, D
Length: 478 amino acids
Theoretical weight: 50.28 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WP51 (Residues: 2-464; Coverage: 100%)
Gene names: Rv1077, cbs
Pfam:
InterPro:
Probable cystathionine beta-synthase Rv1077 in PDB entry 7xoh, assembly 1, front view.
Probable cystathionine beta-synthase Rv1077 in PDB entry 7xoh, assembly 1, side view.
Probable cystathionine beta-synthase Rv1077 in PDB entry 7xoh, assembly 1, top view.
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